ArticleThe Journal of clinical investigation2010
The role of Sirt1 in renal rejuvenation and resistance to stress.
Article in The Journal of clinical investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling Pathway.Aging cell · 2025Article
- Identifying cellular senescence associated genes involved in the progression of end-stage renal disease as new biomarkers.BMC nephrology · 2023Article
- Global research trends and hot spots on autophagy and kidney diseases: a bibliometric analysis from 2000 to 2022.Frontiers in pharmacology · 2023Review
- Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases.Frontiers in cardiovascular medicine · 2021Review
- Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer?Journal of diabetes and its complications · 2017Review
- Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.The Journal of clinical investigation · 2017Article
- Renal Aging: Causes and Consequences.Journal of the American Society of Nephrology : JASN · 2017Review
- Resveratrol attenuates 4-hydroxy-2-hexenal-induced oxidative stress in mouse cortical collecting duct cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes.Mediators of inflammation · 2015Review
- β-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD⁺, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation.Kidney international · 2014Article
- The Role of SIRT1 in Diabetic Kidney Disease.Frontiers in endocrinology · 2014Review
- Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.EMBO molecular medicine · 2013Article
- Ceramide-orchestrated signalling in cancer cells.Nature reviews. Cancer · 2013Review
- Intravenous renal cell transplantation for rats with acute and chronic renal failure.American journal of physiology. Renal physiology · 2012Article
- Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy.Acta pharmacologica Sinica · 2012Article
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Abstract
This issue of the JCI includes studies demonstrating that sirtuin 1 (Sirt1), a NAD+-dependent deacetylase, slows renal senescence and safeguards cells in the renal medulla. Kume et al. demonstrated that caloric restriction protected the aging kidney by preserving renal Sirt1 expression, the latter deacetylating forkhead box O3a (FOXO3a), inducing Bnip 3, and promoting mitochondrial autophagy. Sirt1 expression, as shown by He et al., enabled interstitial cells to withstand the oxidizing medullary environment and exerted antiapoptotic and antifibrotic effects in the obstructed kidney. Sirt1 is thus an important participant in renal cytoprotective responses to aging and stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.