ArticleInvestigative ophthalmology & visual science2010
Cold-sensitive corneal afferents respond to a variety of ocular stimuli central to tear production: implications for dry eye disease.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 105 citations in OpenAlex.
- A novel TRPM8 agonist relieves dry eye discomfort.BMC ophthalmology · 2017Trial
- Infraorbital Skin Application of Menthol Emulsion for Dry Eye Disease: A Randomized Clinical Trial.Ophthalmology and therapy · 2026Article
- Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future.Investigative ophthalmology & visual science · 2026Review
- Validation and Comparative Analysis of a Contemporary Non-Contact Corneal Aesthesiometer.Journal of clinical medicine · 2026Article
- Emerging Technologies in Corneal Nerve Evaluation for Dry Eye and Ocular Surface Disease: A Review.Journal of clinical medicine · 2026Review
- Modulation of corneal sensory processing and pain responses by dry eye and corneal wounding.Frontiers in cellular neuroscience · 2026Article
- Article
- Adverse effects of meteorological factors and air pollutants on dry eye disease: a hospital-based retrospective cohort study.Scientific reports · 2024Article
- One Soul and Several Faces of Evaporative Dry Eye Disease.Journal of clinical medicine · 2024Review
- Cyclosporine A Decreases Dryness-Induced Hyperexcitability of Corneal Cold-Sensitive Nerve Terminals.International journal of molecular sciences · 2023Article
- Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity.The ocular surface · 2022Article
- Transient Receptor Potential Channels: Important Players in Ocular Pain and Dry Eye Disease.Pharmaceutics · 2022Review
- Corneal nerves and their role in dry eye pathophysiology.Experimental eye research · 2022Review
- Neuropathic ocular surface pain: Emerging drug targets and therapeutic implications.Expert opinion on therapeutic targets · 2022Review
- Acute Inhibitory Effects of Antidepressants on Lacrimal Gland Secretion in the Anesthetized Rat.Investigative ophthalmology & visual science · 2021Article
- Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade.Investigative ophthalmology & visual science · 2021Article
- Mechanisms of Peripheral and Central Pain Sensitization: Focus on Ocular Pain.Frontiers in pharmacology · 2021Review
- TRPM8: A Therapeutic Target for Neuroinflammatory Symptoms Induced by Severe Dry Eye Disease.International journal of molecular sciences · 2020Article
- Ocular Surface Pain: A Narrative Review.Ophthalmology and therapy · 2020Review
- Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the response characteristics of the corneal afferents that detect ocular conditions critical to the activation of the "afferent limb" of the lacrimation reflex.
methodsIn isoflurane-anesthetized male rats, trigeminal ganglia were explored extracellularly in vivo to identify the corneal neurons that can be activated by ocular stimuli important to lacrimation. After verifying their receptive field loci to be restricted to the cornea, neural response properties were characterized with a variety of stimuli, such as drying and wetting of the cornea, by applying and removing artificial tears, temperature changes (35 degrees C-15 degrees C and 39 degrees C-51 degrees C), menthol (10-100 microM), and hyperosmolar solutions (NaCl, sucrose; 297-3014 mOsm), applied to the ocular surface.
resultsA specific type of corneal afferent was identified that responded to drying of the ocular surface. These neurons were classified as innocuous "cold" thermoreceptors by their responses to steady state and dynamic temperature changes applied to the cornea. In addition to drying and slight cooling (<1 degree C) of the corneal surface, these neurons were excited by evaporation of tears from the ocular surface and hyperosmolar tears. Moreover, these neurons were activated by noxious thermal stimulation and menthol applied to the corneal surface.
conclusionsThese results demonstrate that innocuous "cold" cornea thermoreceptors are activated by drying of the ocular surface and hyperosmotic solutions, conditions that are consistent with a role in tear production. The authors hypothesize that the dysfunction of these corneal afferents and the lacrimation reflex pathway they activate lead to some forms of dry eye disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.