ArticleJournal of immunology (Baltimore, Md. : 1950)2010
CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Pentanoate modulates B cells to suppress allergic contact hypersensitivity.Scientific reports · 2025Article
- Noncanonical B Cells: Characteristics of Uncharacteristic B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Homeostatic role of B-1 cells in tissue immunity.Frontiers in immunology · 2023Review
- Resident Memory B Cells in Barrier Tissues.Frontiers in immunology · 2022Review
- Skin-Homing Regulatory B Cells Required for Suppression of Cutaneous Inflammation.The Journal of investigative dermatology · 2021Article
- Contact dermatitis.Nature reviews. Disease primers · 2021Review
- Characterization of Organ-Specific Regulatory B Cells Using Single-Cell RNA Sequencing.Frontiers in immunology · 2021Article
- Immunosuppressive Mechanisms of Regulatory B Cells.Frontiers in immunology · 2021Review
- Regulatory functions of B cells and regulatory plasma cells.Biomedical journal · 2019Review
- Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch.Protein & cell · 2019Review
- Skin-Associated B Cells in Health and Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- CD22 Promotes B-1b Cell Responses to T Cell-Independent Type 2 Antigens.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.Nature communications · 2018Article
- PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Dysregulation of peritoneal cavity B1a cells and murine primary biliary cholangitis.Oncotarget · 2016Article
- IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- New insights into heterogeneity of peritoneal B-1a cells.Annals of the New York Academy of Sciences · 2015Review
- Article
- Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Primate B-1 cells generate antigen-specific B cell responses to T cell-independent type 2 antigens.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Although contact hypersensitivity (CHS) has been considered a prototype of T cell-mediated immune reactions, recently a significant contribution of regulatory B cell subsets in the suppression of CHS has been demonstrated. CD22, one of the sialic acid-binding immunoglobulin-like lectins, is a B cell-specific molecule that negatively regulates BCR signaling. To clarify the roles of B cells in CHS, CHS in CD22(-/-) mice was investigated. CD22(-/-) mice showed delayed recovery from CHS reactions compared with that of wild-type mice. Transfer of wild-type peritoneal B-1a cells reversed the prolonged CHS reaction seen in CD22(-/-) mice, and this was blocked by the simultaneous injection with IL-10 receptor Ab. Although CD22(-/-) peritoneal B-1a cells were capable of producing IL-10 at wild-type levels, i.p. injection of differentially labeled wild-type/CD22(-/-) B cells demonstrated that a smaller number of CD22(-/-) B cells resided in lymphoid organs 5 d after CHS elicitation, suggesting a defect in survival or retention in activated CD22(-/-) peritoneal B-1 cells. Thus, our study reveals a regulatory role for peritoneal B-1a cells in CHS. Two distinct regulatory B cell subsets cooperatively inhibit CHS responses. Although splenic CD1d(hi)CD5(+) B cells have a crucial role in suppressing the acute exacerbating phase of CHS, peritoneal B-1a cells are likely to suppress the late remission phase as "regulatory B cells." CD22 deficiency results in disturbed CHS remission by impaired retention or survival of peritoneal B-1a cells that migrate into lymphoid organs.
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