ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 84 citations in OpenAlex.
- Clinical efficacy of a Chinese herbal gel plaster combined with manipulation for lumbar disc herniation: a prospective, randomized, double-blind, placebo-controlled trial.Frontiers in pharmacology · 2026Trial
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- Placebo-induced somatic sensations: a multi-modal study of three different placebo interventions.PloS one · 2015Trial
- Pepper Constituents Enhance the Toxicity and Neurophysiological Effects of Natural Pyrethrins in Insects.Insects · 2026Article
- An exhaustive examination of the research progress in identifying potential JAK inhibitors from natural products: a comprehensive overview.Chinese medicine · 2025Review
- Initial validation of the Mass. General Neuropathy Exam Tool (MAGNET) for evaluation of distal small-fiber neuropathy.Muscle & nerve · 2024Article
- Effects of potassium channel modulators on the responses of mammalian slowly adapting mechanoreceptors.IBRO neuroscience reports · 2022Article
- Design of hydroxy-α-sanshool loaded nanostructured lipid carriers as a potential local anesthetic.Drug delivery · 2022Article
- Touch inhibits touch: sanshool-induced paradoxical tingling reveals perceptual interaction between somatosensory submodalities.Proceedings. Biological sciences · 2021Article
- Review
- Evidence for a novel subcortical mechanism for posterior cingulate cortex atrophy in HIV peripheral neuropathy.Journal of neurovirology · 2020Article
- The Background KInternational journal of molecular sciences · 2020Review
- Chemogenic Subqualities of Mouthfeel.Chemical senses · 2019Review
- Anionic Phospholipids Bind to and Modulate the Activity of Human TRESK Background KMolecular neurobiology · 2019Article
- Spilanthol Enhances Sensitivity to Sodium in Mouse Taste Bud Cells.Chemical senses · 2019Article
- Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy.Cell death & disease · 2019Article
- Tweaking mechanosensors.Nature chemistry · 2018Article
- Article
- Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.British journal of pharmacology · 2016Article
- Sanshool on The Fingertip Interferes with Vibration Detection in a Rapidly-Adapting (RA) Tactile Channel.PloS one · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hydroxy-alpha-sanshool, the active ingredient in plants of the prickly ash plant family, induces robust tingling paresthesia by activating a subset of somatosensory neurons. However, the subtypes and physiological function of sanshool-sensitive neurons remain unknown. Here we use the ex vivo skin-nerve preparation to examine the pattern and intensity with which the sensory terminals of cutaneous neurons respond to hydroxy-alpha-sanshool. We found that sanshool excites virtually all D-hair afferents, a distinct subset of ultrasensitive light-touch receptors in the skin and targets novel populations of Abeta and C fiber nerve afferents. Thus, sanshool provides a novel pharmacological tool for discriminating functional subtypes of cutaneous mechanoreceptors. The identification of sanshool-sensitive fibers represents an essential first step in identifying the cellular and molecular mechanisms underlying tingling paresthesia that accompanies peripheral neuropathy and injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.