ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
"Slow activity transients" in infant rat visual cortex: a spreading synchronous oscillation patterned by retinal waves.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60 citing papers in PubMed, 101 citations in OpenAlex.
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- Evolution of cross-frequency coupling between endogenous oscillations over the temporal cortex in very premature neonates.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Early brain activity: Translations between bedside and laboratory.Progress in neurobiology · 2022Review
- The Newborn's Reaction to Light as the Determinant of the Brain's Activation at Human Birth.Frontiers in integrative neuroscience · 2022Article
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- Aberrant development of excitatory circuits to inhibitory neurons in the primary visual cortex after neonatal binocular enucleation.Scientific reports · 2021Article
- Neurophysiology of the Developing Cerebral Cortex: What We Have Learned and What We Need to Know.Frontiers in cellular neuroscience · 2021Review
- Spontaneous Afferent Activity Carves Olfactory Circuits.Frontiers in cellular neuroscience · 2021Article
- The intimate relationship between coalescent generators in very premature human newborn brains: Quantifying the coupling of nested endogenous oscillations.Human brain mapping · 2020Article
- GABAergic interneurons excite neonatal hippocampus in vivo.Science advances · 2020Article
- Progressive alignment of inhibitory and excitatory delay may drive a rapid developmental switch in cortical network dynamics.Journal of neurophysiology · 2020Article
- Caffeine Restores Background EEG Activity Independent of Infarct Reduction after Neonatal Hypoxic Ischemic Brain Injury.Developmental neuroscience · 2020Article
- Cross-Talk of Low-Level Sensory and High-Level Cognitive Processing: Development, Mechanisms, and Relevance for Cross-Modal Abilities of the Brain.Frontiers in neurorobotics · 2020Review
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- Thalamic inhibitory circuits and network activity development.Brain research · 2019Review
- Emergence of Coordinated Activity in the Developing Entorhinal-Hippocampal Network.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Neural Correlates of Anesthesia in Newborn Mice and Humans.Frontiers in neural circuits · 2019Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
A primary feature of the preterm infant electroencephalogram is the presence of large infra-slow potentials containing rapid oscillations called slow activity transients (SATs). Such activity has not been described in animal models, and their generative mechanisms are unknown. Here we use direct-current and multisite extracellular, as well as whole-cell, recording in vivo to demonstrate the existence of regularly repeating SATs in the visual cortex of infant rats before eye opening. Present only in absence of anesthesia, SATs at postnatal day 10-11 were identifiable as a separate group of long-duration (approximately 10 s) events that consisted of large (>1 mV) negative local-field potentials produced by the summation of multiple bursts of rapid oscillatory activity (15-30 Hz). SATs synchronized the vast majority of neuronal activity (87%) in the visual cortex before eye opening. Enucleation eliminated SATs, and their duration, interevent interval, and sub-burst structure matched those of phase III retinal waves recorded in vitro. Retinal waves, however, lacked rapid oscillations, suggesting that they arise centrally. Multielectrode recordings showed that SATs spread horizontally in cortex and synchronize activity at coactive locales via the rapid oscillations. SATs were clearly different from ongoing cortical activity, which was observable as a separate class of short bursts from postnatal day 9. Together, our data suggest that, in vivo, early cortical activity is primarily determined by peripheral inputs-retinal waves in visual cortex-that provide excitatory input, and by thalamocortical circuitry, which transforms this input to beta oscillations. We propose that the synchronous oscillations of SATs participate in the formation of visual circuitry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.