ArticlePlant physiology2010
Deregulated copper transport affects Arabidopsis development especially in the absence of environmental cycles.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 124 citations in OpenAlex.
- Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels.The Journal of clinical investigation · 2026Article
- Magnesium: An overlooked signalling ion in plant physiology and circadian regulation.Quantitative plant biology · 2026Review
- Clathrin-mediated trafficking regulates copper tolerance by modulating the localization of HEAVY METAL ATPase 5 in Arabidopsis root cells.Plant physiology · 2025Article
- Copper connections: coordinating transport, sensing and systemic signalling in plants.Quantitative plant biology · 2025Review
- The Transcription Factor VvbHLH053 Regulates the Expression of Copper Homeostasis-Associated GenesInternational journal of molecular sciences · 2024Article
- Molecular Mechanisms of Plant Responses to Copper: From Deficiency to Excess.International journal of molecular sciences · 2024Review
- Distinct function of Chlamydomonas CTRA-CTR transporters in Cu assimilation and intracellular mobilization.Metallomics : integrated biometal science · 2024Article
- Molecular Responses of Red Ripe Tomato Fruit to Copper Deficiency Stress.Plants (Basel, Switzerland) · 2023Article
- The circadian clock ticks in plant stress responses.Stress biology · 2022Review
- Article
- Increase in Phytoextraction Potential by Genome Editing and Transformation: A Review.Plants (Basel, Switzerland) · 2021Review
- Transcriptome Profiling of Cu Stressed Petunia Petals Reveals Candidate Genes Involved in Fe and Cu Crosstalk.International journal of molecular sciences · 2021Article
- The Copper-microRNA Pathway Is Integrated with Developmental and Environmental Stress Responses inInternational journal of molecular sciences · 2021Article
- Magnesium maintains the length of the circadian period in Arabidopsis.Plant physiology · 2021Article
- Article
- Melatonin Relations with Energy Metabolism as Possibly Involved in Fatal Mountain Road Traffic Accidents.International journal of molecular sciences · 2020Review
- Deregulated High Affinity Copper Transport Alters Iron Homeostasis inFrontiers in plant science · 2020Article
- The Geomagnetic Field Is a Contributing Factor for an Efficient Iron Uptake inFrontiers in plant science · 2020Article
- Overexpression of native Musa-miR397 enhances plant biomass without compromising abiotic stress tolerance in banana.Scientific reports · 2019Article
- Characterization of the Copper Transporters fromInternational journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper is an essential cofactor for key processes in plants, but it exerts harmful effects when in excess. Previous work has shown that the Arabidopsis (Arabidopsis thaliana) COPT1 high-affinity copper transport protein participates in copper uptake through plant root tips. Here, we show that COPT1 protein localizes to the plasma membrane of Arabidopsis cells and the phenotypic effects of transgenic plants overexpressing either COPT1 or COPT3, the latter being another high-affinity copper transport protein family member. Both transgenic lines exhibit increased endogenous copper levels and are sensitive to the copper in the growth medium. Additional phenotypes include decreased hypocotyl growth in red light and differentially affected flowering times depending on the photoperiod. Furthermore, in the absence of environmental cycles, such as light and temperature, the survival of plants overexpressing COPT1 or COPT3 is compromised. Consistent with altered circadian rhythms, the expression of the nuclear circadian clock genes CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) is substantially reduced in either COPT1- or COPT3-overexpressing plants. Copper affects the amplitude and the phase, but not the period, of the CCA1 and LHY oscillations in wild-type plants. Copper also drives a reduction in the expression of circadian clock output genes. These results reveal that the spatiotemporal control of copper transport is a key aspect of metal homeostasis that is required for Arabidopsis fitness, especially in the absence of environmental cues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.