ArticleDevelopment (Cambridge, England)2010
The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Caenorhabditis elegans LET-381 and DMD-4 control development of the mesodermal HMC endothelial cell.Development (Cambridge, England) · 2025Article
- SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development.PLoS genetics · 2025Article
- SEM-2/SoxC regulates multiple aspects ofbioRxiv : the preprint server for biology · 2024Article
- LET-381/FoxF and its target UNC-30/Pitx2 specify and maintain the molecular identity of C. elegans mesodermal glia that regulate motor behavior.The EMBO journal · 2024Article
- Article
- MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis.European journal of medical research · 2023Review
- Article
- FGF signaling acts on different levels of mesoderm development within Spiralia.Development (Cambridge, England) · 2021Article
- Planarians (Platyhelminthes)-An Emerging Model Organism for Investigating Innate Immune Mechanisms.Frontiers in cellular and infection microbiology · 2021Review
- A high-content imaging approach to profileDevelopment (Cambridge, England) · 2019Article
- foxF-1 Controls Specification of Non-body Wall Muscle and Phagocytic Cells in Planarians.Current biology : CB · 2018Article
- Overlapping cell population expression profiling and regulatory inference in C. elegans.BMC genomics · 2016Article
- Article
- Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.PLoS genetics · 2015Article
- Mesodermal gene expression during the embryonic and larval development of the articulate brachiopod Terebratalia transversa.EvoDevo · 2015Article
- A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. elegans.Developmental biology · 2014Article
- High-throughput capturing and characterization of mutations in essential genes of Caenorhabditis elegans.BMC genomics · 2014Article
- Transcriptional regulation of gene expression in C. elegans.WormBook : the online review of C. elegans biology · 2013Review
- Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.Genetics · 2011Article
- The Caenorhabditis elegans T-box factor MLS-1 requires Groucho co-repressor interaction for uterine muscle specification.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Forkhead transcription factors play crucial and diverse roles in mesoderm development. In particular, FoxF and FoxC genes are, respectively, involved in the development of visceral/splanchnic mesoderm and non-visceral mesoderm in coelomate animals. Here, we show at single-cell resolution that, in the pseudocoelomate nematode C. elegans, the single FoxF/FoxC transcription factor LET-381 functions in a feed-forward mechanism in the specification and differentiation of the non-muscle mesodermal cells, the coelomocytes (CCs). LET-381/FoxF directly activates the CC specification factor, the Six2 homeodomain protein CEH-34, and functions cooperatively with CEH-34/Six2 to directly activate genes required for CC differentiation. Our results unify a diverse set of studies on the functions of FoxF/FoxC factors and provide a model for how FoxF/FoxC factors function during mesoderm development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.