ArticleAmerican journal of physiology. Renal physiology2010
P2X(1) receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo.
Article in American journal of physiology. Renal physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Targeting P2X Receptors-Current Progress in Sepsis.International journal of inflammation · 2025Review
- Molecular insights into P2X signalling cascades in acute kidney injury.Purinergic signalling · 2024Review
- Purinergic Receptor Antagonists: A Complementary Treatment for Hypertension.Pharmaceuticals (Basel, Switzerland) · 2024Review
- [New concepts in the physiopathology of hypertension. Purinergic receptors].Archivos de cardiologia de Mexico · 2024Review
- P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response.Molecular metabolism · 2020Article
- Purinoceptors, renal microvascular function and hypertension.Physiological research · 2020Review
- The Role of P2X7 Purinergic Receptors in the Renal Inflammation Associated with Angiotensin II-induced Hypertension.International journal of molecular sciences · 2020Article
- Extracellular Nucleotides and P2 Receptors in Renal Function.Physiological reviews · 2020Review
- Integration of purinergic and angiotensin II receptor function in renal vascular responses and renal injury in angiotensin II-dependent hypertension.Purinergic signalling · 2019Review
- Acute toll-like receptor 4 activation impairs rat renal microvascular autoregulatory behaviour.Acta physiologica (Oxford, England) · 2017Article
- Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats.American journal of physiology. Renal physiology · 2016Article
- Endothelin contributes to blunted renal autoregulation observed with a high-salt diet.American journal of physiology. Renal physiology · 2015Article
- The dark side of extracellular ATP in kidney diseases.Journal of the American Society of Nephrology : JASN · 2015Review
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Regulation of renal function and blood pressure control by P2 purinoceptors in the kidney.Current opinion in pharmacology · 2015Review
- Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model.Intensive care medicine experimental · 2014Article
- Vascular smooth muscle cells from small human omental arteries express P2X1 and P2X4 receptor subunits.Purinergic signalling · 2014Article
- High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism.American journal of physiology. Renal physiology · 2014Article
- Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension.American journal of physiology. Renal physiology · 2014Article
- Purinergic signalling in the kidney in health and disease.Purinergic signalling · 2014Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In vitro experiments demonstrate that P2X(1) receptor activation is important for normal afferent arteriolar autoregulatory behavior, but direct in vivo evidence for this relationship occurring in the whole kidney is unavailable. Experiments were performed to test the hypothesis that P2X(1) receptors are important for autoregulation of whole kidney blood flow. Renal blood flow (RBF) was measured in anesthetized male Sprague-Dawley rats before and during P2 receptor blockade with PPADS, P2X(1) receptor blockade with IP5I, or A(1) receptor blockade with DPCPX. Both P2X(1) and A(1) receptor stimulation with alpha,beta-methylene ATP and CPA, respectively, caused dose-dependent decreases in RBF. Administration of either PPADS or IP5I significantly blocked P2X(1) receptor stimulation. Likewise, administration of DPCPX significantly blocked A(1) receptor activation to CPA. Autoregulatory behavior was assessed by measuring RBF responses to reductions in renal perfusion pressure. In vehicle-infused rats, as pressure was decreased from 120 to 100 mmHg, there was no decrease in RBF. However, in either PPADS- or IP5I-infused rats, each decrease in pressure resulted in a significant decrease in RBF, demonstrating loss of autoregulatory ability. In DPCPX-infused rats, reductions in pressure did not cause significant reductions in RBF over the pressure range of 100-120 mmHg, but the autoregulatory curve tended to be steeper than vehicle-infused rats over the range of 80-100 mmHg, suggesting that A(1) receptors may influence RBF at lower pressures. These findings are consistent with in vitro data from afferent arterioles and support the hypothesis that P2X(1) receptor activation is important for whole kidney autoregulation in vivo.
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