Evidence map›Paper›PMID 20335089›Full record

ArticleIEEE transactions on medical imaging2010

FRATS: Functional Regression Analysis of DTI Tract Statistics.

Hongtu Zhu, Martin Styner, Niansheng Tang, Zhexing Liu, Weili Lin, John H Gilmore

Abstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Parametrization of white matter manifold-like structures using principal surfaces.Journal of the American Statistical Association · 2016
    Article
  6. Article
  7. Cook's Distance Measures for Varying Coefficient Models with Functional Responses.Technometrics : a journal of statistics for the physical, chemical, and engineering sciences · 2015
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. A longitudinal functional analysis framework for analysis of white matter tract statistics.Information processing in medical imaging : proceedings of the ... conference · 2013
    Article
  13. Article
  14. Article
  15. Article
  16. Local Polynomial Regression for Symmetric Positive Definite Matrices.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2012
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongtu ZhuDepartment of Biostatistics, and Biomedical ResearchImaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC27599, USA. hzhu@bios.unc.edu
Martin Styner
Niansheng Tang
Zhexing Liu
Weili Lin
John H Gilmore

Funding

UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
Washington University ConsoritumU54EB005149 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI SHARP, GREGORY · 2004 to 2013
$39.3M
UNC MRDD Research CenterP30HD003110 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL · 1985 to 2012
$28.7M
Prospective study of the onset of schizophreniaP50MH064065 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2002 to 2011
$19.6M
Early Brain Development in TwinsR01MH070890 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2004 to 2014
$5.3M
Early Brain Development in One and Two Year OldsR01HD053000 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2007 to 2018
$4.4M
Early Brain Development in TwinsU01MH070890 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2015 to 2019
$2.9M
Statistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9M
Characterization of Normal Brain Development Using Parallel MRIR01NS055754 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, WEILI · 2007 to 2011
$2.5M
Longitudinal Analysis of Biomedical Imaging DataR21AG033387 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHU, HONGTU · 2009 to 2010
$334k
NCRR NIH HHS UL1 RR025747NCRR NIH HHS UL1-RR025747-01NIA NIH HHS AG033387NIA NIH HHS R21 AG033387NIBIB NIH HHS U54 EB005149NIBIB NIH HHS U54 EB005149-01NICHD NIH HHS HD 03110NICHD NIH HHS HD053000NICHD NIH HHS P30 HD003110NICHD NIH HHS R01 HD053000NIMH NIH HHS MH064065NIMH NIH HHS MH070890NIMH NIH HHS MH086633NIMH NIH HHS P50 MH064065NIMH NIH HHS R01 MH070890NIMH NIH HHS R01 MH086633NIMH NIH HHS U01 MH070890NINDS NIH HHS R01 NS055754NINDS NIH HHS R01NS055754
6 · The paper itself

Abstract

Diffusion tensor imaging (DTI) provides important information on the structure of white matter fiber bundles as well as detailed tissue properties along these fiber bundles in vivo. This paper presents a functional regression framework, called FRATS, for the analysis of multiple diffusion properties along fiber bundle as functions in an infinite dimensional space and their association with a set of covariates of interest, such as age, diagnostic status and gender, in real applications. The functional regression framework consists of four integrated components: the local polynomial kernel method for smoothing multiple diffusion properties along individual fiber bundles, a functional linear model for characterizing the association between fiber bundle diffusion properties and a set of covariates, a global test statistic for testing hypotheses of interest, and a resampling method for approximating the p-value of the global test statistic. The proposed methodology is applied to characterizing the development of five diffusion properties including fractional anisotropy, mean diffusivity, and the three eigenvalues of diffusion tensor along the splenium of the corpus callosum tract and the right internal capsule tract in a clinical study of neurodevelopment. Significant age and gestational age effects on the five diffusion properties were found in both tracts. The resulting analysis pipeline can be used for understanding normal brain development, the neural bases of neuropsychiatric disorders, and the joint effects of environmental and genetic factors on white matter fiber bundles.

Indexed as

AlgorithmsModels, NeurologicalBrainComputer SimulationData Interpretation, StatisticalDiffusion Tensor ImagingHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalModels, StatisticalNerve Fibers, MyelinatedRegression AnalysisReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID20335089
PMCPMC2896997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.