ReviewCurrent opinion in immunology2010
Multiple hats for natural killers.
Review in Current opinion in immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- The GFI1-FOXO1 axis regulates NK cell maturation and function.Nature communications · 2026Article
- Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A.The Journal of biological chemistry · 2020Article
- dropClust: efficient clustering of ultra-large scRNA-seq data.Nucleic acids research · 2018Article
- Transcriptional and post-transcriptional regulation of NK cell development and function.Clinical immunology (Orlando, Fla.) · 2017Review
- MicroRNA-15/16 Antagonizes Myb To Control NK Cell Maturation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function.Immunity · 2015Article
- Immune Cell Identity: Perspective from a Palimpsest.Perspectives in biology and medicine · 2015Article
- microRNA management of NK-cell developmental and functional programs.European journal of immunology · 2014Review
- Innate lymphoid cells facilitate NK cell development through a lymphotoxin-mediated stromal microenvironment.The Journal of experimental medicine · 2014Article
- Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300.Nucleic acids research · 2014Article
- Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.Molecular and cellular biology · 2014Article
- Large granular lymphocytosis during dasatinib therapy.Cancer biology & therapy · 2014Review
- MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- MicroRNA regulation of natural killer cells.Frontiers in immunology · 2013Article
- Regulating the immune system via IL-15 transpresentation.Cytokine · 2012Review
- Natural killer cell regulation by microRNAs in health and disease.Journal of biomedicine & biotechnology · 2012Review
- Transcriptional control of natural killer cell differentiation and function.Cellular and molecular life sciences : CMLS · 2011Review
- NK cell development, homeostasis and function: parallels with CD8⁺ T cells.Nature reviews. Immunology · 2011Review
- T cell lineage commitment: identity and renunciation.Journal of immunology (Baltimore, Md. : 1950) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Natural killer (NK) cells are a subset of lymphocytes that kill virus-infected or cancerous cells and influence adaptive immune responses via production of inflammatory cytokines. Unlike B and T lymphocytes, no transcription factors have been identified that are essential for the emergence of NK cell progenitors from their multipotent precursors. We argue that this dearth of essential factors is because of the expression of redundant transcription factors that function at the earliest stages of development. However, multiple essential transcription factors have been identified at later stages of development. Recent studies have revealed novel subsets of NK cells with differing potential for target cell lysis and cytokine production. How these subsets arise from the conventional pathway of NK cell development and identification of the transcriptional networks that control their development are major challenges for future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.