ArticleRadiation research2010
Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy.
Article in Radiation research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study.Cancer reports (Hoboken, N.J.) · 2022Review
- Therapeutic effects of Co-Venenum Bufonis Oral Liquid on radiation-induced esophagitis in rats.Experimental animals · 2020Article
- Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.Science translational medicine · 2018Article
- The protein PprI provides protection against radiation injury in human and mouse cells.Scientific reports · 2016Article
- CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection.Free radical biology & medicine · 2015Article
- Gene therapy for radioprotection.Cancer gene therapy · 2015Review
- Antioxidant Approaches to Management of Ionizing Irradiation Injury.Antioxidants (Basel, Switzerland) · 2015Article
- Radiation-Induced Esophagitis is Mitigated by Soy Isoflavones.Frontiers in oncology · 2015Article
- HIV-TAT mediated protein transduction of Cu/Zn-superoxide dismutase-1 (SOD1) protects skin cells from ionizing radiation.Radiation oncology (London, England) · 2013Article
- Hematopoietic stem cell regeneration enhanced by ectopic expression of ROS-detoxifying enzymes in transplant mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- The diverse and complex roles of radiation on cancer treatment: therapeutic target and genome maintenance.American journal of cancer research · 2012Article
- Strategies for discovery of small molecule radiation protectors and radiation mitigators.Frontiers in oncology · 2011Article
- Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells.In vivo (Athens, Greece)Article
- Esophageal radioprotection by swallowed JP4-039/F15 in thoracic-irradiated mice with transgenic lung tumors.In vivo (Athens, Greece)Article
- Transcriptome Profiling Unveils a Critical Role of IL-17 Signaling-Mediated Inflammation in Radiation-Induced Esophageal Injury in Rats.Dose-response : a publication of International Hormesis SocietyArticle
- Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Radiation-induced DNA damage is a precursor to mutagenesis and cytotoxicity. During radiotherapy, exposure of healthy tissues can lead to severe side effects. We explored the potential of mitochondrial SOD (MnSOD) gene therapy to protect esophageal, pancreatic and bone marrow cells from radiation-induced genomic instability. Specifically, we measured the frequency of homologous recombination (HR) at an integrated transgene in the Fluorescent Yellow Direct Repeat (FYDR) mice, in which an HR event can give rise to a fluorescent signal. Mitochondrial SOD plasmid/liposome complex (MnSOD-PL) was administered to esophageal cells 24 h prior to 29 Gy upper-body irradiation. Single cell suspensions from FYDR, positive control FYDR-REC, and negative control C57BL/6NHsd (wild-type) mouse esophagus, pancreas and bone marrow were evaluated by flow cytometry. Radiation induced a statistically significant increase in HR 7 days after irradiation compared to unirradiated FYDR mice. MnSOD-PL significantly reduced the induction of HR by radiation at day 7 and also reduced the level of HR in the pancreas. Irradiation of the femur and tibial marrow with 8 Gy also induced a significant increase in HR at 7 days. Radioprotection by intraesophageal administration of MnSOD-PL was correlated with a reduced level of radiation-induced HR in esophageal cells. These results demonstrate the efficacy of MnSOD-PL for suppressing radiation-induced HR in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.