SynthesisIntensive care medicine2010
Outcome of acute kidney injury in severe burns: a systematic review and meta-analysis.
Synthesis in Intensive care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Meta-Analysis of Renal Replacement Therapy for Burn Patients: Incidence Rate, Mortality, and Renal Outcome.Frontiers in medicine · 2021Pooled it
- Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis.Critical care (London, England) · 2020Pooled it
- Poor methodological quality and reporting standards of systematic reviews in burn care management.International wound journal · 2017Pooled it
- High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial.Critical care (London, England) · 2017Trial
- The prevalence, risk factors, and in-hospital mortality of acute kidney injury according to KDIGO criteria in burn patients.Renal failure · 2025Article
- Gastrointestinal insufficiency is a risk factor for severely burned patients: a case-control study among 185 victims in Kunshan explosion.BMC gastroenterology · 2025Article
- Post-burns persistent inflammation leads to kidney PANoptosis with Caspases pathway activation.Heliyon · 2025Article
- Article
- Acute kidney injury in pediatric burn patients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Extracorporeal Organ Support for Burn-Injured Patients.European burn journal · 2024Review
- Acute kidney injury in patients with burns.Nature reviews. Nephrology · 2024Review
- Long-Term Effects of Severe Burns on the Kidneys: Research Advances and Potential Therapeutic Approaches.Journal of inflammation research · 2023Review
- Medical and Surgical Care of Critical Burn Patients: A Comprehensive Review of Current Evidence and Practice.Cureus · 2022Review
- Comparative Analysis of Composite Mortality Prediction Scores in Intensive Care Burn Patients.International journal of environmental research and public health · 2022Article
- Burn-Induced Acute Kidney Injury-Two-Lane Road: From Molecular to Clinical Aspects.International journal of molecular sciences · 2022Review
- Meropenem pharmacokinetics in critically ill patients with or without burn treated with or without continuous veno-venous haemofiltration.British journal of clinical pharmacology · 2022Article
- Hypoxia-Inducible Factors and Burn-Associated Acute Kidney Injury-A New Paradigm?International journal of molecular sciences · 2022Review
- Incidence and risk factors of acute kidney injury in severely burned patients in Mulago Hospital, Uganda - a prospective cohort.International journal of burns and trauma · 2022Article
- Long-Term Preservation of Renal Function in Septic Shock Burn Patients Requiring Renal Replacement Therapy for Acute Kidney Injury.Journal of clinical medicine · 2021Article
- Epidemiology and outcomes of bloodstream infections in severe burn patients: a six-year retrospective study.Antimicrobial resistance and infection control · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe main objective of this review was to analyse the prevalence and outcome of acute kidney injury (AKI) in patients with severe burn injury. AKI is a common complication in patients with severe burn injury and one of the major causes of death (often combined with other organ dysfunctions). Several definitions of AKI have been used, but the RIFLE 'consensus' classification is nowadays considered the gold standard, enabling a more objective comparison of populations.
methodsWe performed a systematic literature search (1960-2009), involving PubMed, the Web of Science, the search engine Google and textbooks. Reference lists and the Science Citation Index search were also consulted. Attributable mortality was assessed by performing a meta-analysis.
resultsThis search yielded 57 articles and abstracts with relevant epidemiologic data of AKI in the burn population. Of these, 30 contained complete mortality data of the burn and control population, which revealed a 3- to 6-fold higher mortality for AKI patients in univariate analysis, depending on the applied definition. When defined by the RIFLE consensus classification, AKI occurred in one quarter of patients with severe burn injury (median mortality of 34.9%), and when defined by the need for renal replacement therapy (RRT), AKI occurred in 3% (median mortality of 80%). The prevalence of AKI slightly increased, but AKI-RRT decreased. However, the outcome in both groups improved.
conclusionDespite the wide variation of the analysed burn populations and definitions of AKI, this review clearly showed that AKI remains prevalent and is associated with increased mortality in patients with severe burn injury.
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