Evidence map›Paper›PMID 20333321›Full record

ArticleMolecular and cellular pharmacology2009

Anti-Inflammatory Agents for Cancer Therapy.

Elizabeth R Rayburn, Scharri J Ezell, Ruiwen Zhang

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 1 synthesis or guideline pooled it, 340 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Food science & nutrition · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Elizabeth R RayburnDepartment of Pharmacology and Toxicology, Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama.
Scharri J Ezell
Ruiwen Zhang
University of Alabama at Birmingham · US

Funding

Dietary Chemopreventive Components/Oncogene Interaction and CancerR01CA121211 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHANG, RUIWEN · 2007 to 2011
$1.4M
MDM2 AS A NEGATIVE REGULATOR OF P21 WAF1/CIP1R01CA112029 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHANG, RUIWEN · 2005 to 2009
$1.3M
CANCER GENE THERAPY TRAINING PROGRAMT32CA075930 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CURIEL, DAVID TERRY · 1998 to 2008
$1.1M
NCI NIH HHS R01 CA112029NCI NIH HHS R01 CA121211NCI NIH HHS T32 CA075930
6 · The paper itself

Abstract

Inflammation is closely linked to cancer, and many anti-cancer agents are also used to treat inflammatory diseases, such as rheumatoid arthritis. Moreover, chronic inflammation increases the risk for various cancers, indicating that eliminating inflammation may represent a valid strategy for cancer prevention and therapy. This article explores the relationship between inflammation and cancer with an emphasis on epidemiological evidence, summarizes the current use of anti-inflammatory agents for cancer prevention and therapy, and describes the mechanisms underlying the anti-cancer effects of anti-inflammatory agents. Since monotherapy is generally insufficient for treating cancer, the combined use of anti-inflammatory agents and conventional cancer therapy is also a focal point in discussion. In addition, we also briefly describe future directions that should be explored for anti-cancer anti-inflammatory agents.

Identifiers

PMID20333321
PMCPMC2843097
OpenAlexW2094156804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.