ArticlePLoS genetics2010
Parental genome dosage imbalance deregulates imprinting in Arabidopsis.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- CrAGL62 and potential paternally expressed gene CrbZIP contribute to paternal-excess postzygotic barriers in citrus.The New phytologist · 2026Article
- Epigenetics and plant hormone dynamics: a functional and methodological perspective.Journal of experimental botany · 2024Review
- Regulation of DNA Methylation During Plant Endosperm Development.Frontiers in genetics · 2022Review
- Hybrid seed incompatibility in Capsella is connected to chromatin condensation defects in the endosperm.PLoS genetics · 2021Article
- The maternally expressed polycomb group genePlant communications · 2021Article
- Structural Maintenance of Chromosomes 5/6 Complex Is Necessary for Tetraploid Genome Stability inFrontiers in plant science · 2021Article
- Taking the Wheel -Frontiers in plant science · 2021Review
- Morphological Features of the Anther Development in Tomato Plants with Non-Specific Male Sterility.Biology · 2020Article
- Article
- Article
- Establishing the cell biology of apomictic reproduction in diploid Boechera stricta (Brassicaceae).Annals of botany · 2018Article
- Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis.Nature genetics · 2018Article
- Incidence and developmental timing of endosperm failure in post-zygotic isolation between wild tomato lineages.Annals of botany · 2018Article
- Parental Genome Imbalance Causes Post-Zygotic Seed Lethality and Deregulates Imprinting in Rice.Rice (New York, N.Y.) · 2016Article
- Genomic imprinting, disrupted placental expression, and speciation.Evolution; international journal of organic evolution · 2016Article
- Genomic Imprinting in the Endosperm Is Systematically Perturbed in Abortive Hybrid Tomato Seeds.Molecular biology and evolution · 2016Article
- Evolution and Molecular Control of Hybrid Incompatibility in Plants.Frontiers in plant science · 2016Review
- Paternally expressed imprinted genes establish postzygotic hybridization barriers in Arabidopsis thaliana.eLife · 2015Article
- Epigenetic and developmental regulation in plant polyploids.Current opinion in plant biology · 2015Review
- Imprinted gene expression in hybrids: perturbed mechanisms and evolutionary implications.Heredity · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals and in plants, parental genome dosage imbalance deregulates embryo growth and might be involved in reproductive isolation between emerging new species. Increased dosage of maternal genomes represses growth while an increased dosage of paternal genomes has the opposite effect. These observations led to the discovery of imprinted genes, which are expressed by a single parental allele. It was further proposed in the frame of the parental conflict theory that parental genome imbalances are directly mirrored by antagonistic regulations of imprinted genes encoding maternal growth inhibitors and paternal growth enhancers. However these hypotheses were never tested directly. Here, we investigated the effect of parental genome imbalance on the expression of Arabidopsis imprinted genes FERTILIZATION INDEPENDENT SEED2 (FIS2) and FLOWERING WAGENINGEN (FWA) controlled by DNA methylation, and MEDEA (MEA) and PHERES1 (PHE1) controlled by histone methylation. Genome dosage imbalance deregulated the expression of FIS2 and PHE1 in an antagonistic manner. In addition increased dosage of inactive alleles caused a loss of imprinting of FIS2 and MEA. Although FIS2 controls histone methylation, which represses MEA and PHE1 expression, the changes of PHE1 and MEA expression could not be fully accounted for by the corresponding fluctuations of FIS2 expression. Our results show that parental genome dosage imbalance deregulates imprinting using mechanisms, which are independent from known regulators of imprinting. The complexity of the network of regulations between expressed and silenced alleles of imprinted genes activated in response to parental dosage imbalance does not support simple models derived from the parental conflict hypothesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.