ArticleGenome biology and evolution2010
Conservation of neutral substitution rate and substitutional asymmetries in mammalian genes.
Article in Genome biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Mutation dynamics of CpG dinucleotides during a recent event of vertebrate diversification.Epigenetics · 2019Article
- Periodic Variation of Mutation Rates in Bacterial Genomes Associated with Replication Timing.mBio · 2018Article
- Linking the DNA strand asymmetry to the spatio-temporal replication program. I. About the role of the replication fork polarity in genome evolution.The European physical journal. E, Soft matter · 2012Article
- The transcript-centric mutations in human genomes.Genomics, proteomics & bioinformatics · 2012Article
- Article
- Intronic AT skew is a defendable proxy for germline transcription but does not predict crossing-over or protein evolution rates in Drosophila melanogaster.Journal of molecular evolution · 2010Article
- Molecular evolution of genes in avian genomes.Genome biology · 2010Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local variation in neutral substitution rate across mammalian genomes is governed by several factors, including sequence context variables and structural variables. In addition, the interplay of replication and transcription, known to induce a strand bias in mutation rate, gives rise to variation in substitutional strand asymmetries. Here, we address the conservation of variation in mutation rate and substitutional strand asymmetries using primate- and rodent-specific repeat elements located within the introns of protein-coding genes. We find significant but weak conservation of local mutation rates between human and mouse orthologs. Likewise, substitutional strand asymmetries are conserved between human and mouse, where substitution rate asymmetries show a higher degree of conservation than mutation rate. Moreover, we provide evidence that replication and transcription are correlated to the strength of substitutional asymmetries. The effect of transcription is particularly visible for genes with highly conserved gene expression. In comparison with replication and transcription, mutation rate influences the strength of substitutional asymmetries only marginally.
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