ArticleGenome biology and evolution2009
Nucleotide substitution bias within the genus Drosophila affects the pattern of proteome evolution.
Article in Genome biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The birth, death, and evolutionary compensation of uORFs in Drosophila.Nucleic acids research · 2026Article
- The Mutational Robustness of the Genetic Code and Codon Usage in Environmental Context: A Non-Extremophilic Preference?Life (Basel, Switzerland) · 2021Article
- Phylogenetic analysis of mutational robustness based on codon usage supports that the standard genetic code does not prefer extreme environments.Scientific reports · 2021Article
- GC bias lead to increased small amino acids and random coils of proteins in cold-water fishes.BMC genomics · 2018Article
- GRASP [Genomic Resource Access for Stoichioproteomics]: comparative explorations of the atomic content of 12 Drosophila proteomes.BMC genomics · 2013Article
- Modeling compositional dynamics based on GC and purine contents of protein-coding sequences.Biology direct · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
The availability of complete genome sequences for 12 Drosophila species provides an unprecedented resource for large-scale studies of genome evolution. In this study, we looked for correlated shifts in the patterns of genome and proteome evolution within the genus Drosophila. Specifically, we asked if the nucleotide composition of the Drosophila willistoni genome--which is significantly less GC rich than the other 11 sequenced Drosophila genomes--is reflected in an altered pattern of amino acid substitutions in the encoded proteins. Our results show that this is indeed the case: There are large and highly significant asymmetries in the patterns of amino acid substitution between D. willistoni and Drosophila melanogaster, and they are in the direction predicted by the nucleotide biases. The implication of this result, combined with previous studies on long-term proteome evolution, is that substitutional biases at the DNA level can be a major factor in determining both the long-term and the short-term directions of proteome evolution.
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