ArticleMolecular psychiatry2010
Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease.
Article in Molecular psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models.Translational psychiatry · 2012Pooled it
- Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease.American journal of human genetics · 2016Trial
- The Immunologic Function of the Choroid Plexus: A Gateway to Immunomodulatory Therapy in Injury Models of the Central Nervous System.International journal of molecular sciences · 2026Review
- Bacillus Calmette-Guérin (BCG) Vaccination and the Immune-Brain Axis: Implications for Neuroprotection and Neurodegenerative Disease.Vaccines · 2026Review
- Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke.Journal of neuroinflammation · 2024Review
- Inflammation in Posttraumatic Stress Disorder: Dysregulation or Recalibration?Current neuropharmacology · 2024Article
- Mitochondria-Related Candidate Genes and Diagnostic Model to Predict Late-Onset Alzheimer's Disease and Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2024Article
- Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice.Human vaccines & immunotherapeutics · 2022Article
- DCE-MRI of Brain Fluid Barriers:Tissue barriers · 2022Article
- Review
- Cell Clearing Systems Bridging Neuro-Immunity and Synaptic Plasticity.International journal of molecular sciences · 2019Review
- A Sentinel in the Crosstalk Between the Nervous and Immune System: The (Immuno)-Proteasome.Frontiers in immunology · 2019Review
- CD4Frontiers in synaptic neuroscience · 2018Article
- Inflammatory Response in the CNS: Friend or Foe?Molecular neurobiology · 2017Review
- Contributions of the adaptive immune system to mood regulation: Mechanisms and pathways of neuroimmune interactions.Progress in neuro-psychopharmacology & biological psychiatry · 2017Review
- Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men.Human genetics · 2017Review
- Therapeutic Implications of Brain-Immune Interactions: Treatment in Translation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Evolution, immunity and the emergence of brain superautoantigens.F1000Research · 2017Article
- Therapeutic effects of stress-programmed lymphocytes transferred to chronically stressed mice.Progress in neuro-psychopharmacology & biological psychiatry · 2016Article
- Molecular mechanisms of D-cycloserine in facilitating fear extinction: insights from RNAseq.Metabolic brain disease · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating immune cells support hippocampal neurogenesis, spatial memory, expression of brain-derived neurotrophic factor, and resilience to stress. Nevertheless, considering the immune privileged status of the central nervous system (CNS), such cells were assumed to be excluded from the healthy brain. It is evident, however, that the CNS is continuously surveyed by leukocytes, though their function is still a mystery. Coupling this routine leukocyte trafficking with the function attributed to circulating T cells in brain plasticity led us to propose here that CNS immunosurveillance is an integral part of the functioning brain. Anatomical restriction of selected self-recognizing leukocytes to the brain's borders and fluids (cerebrospinal fluid) not only supports the brain's activity, but also controls the potential aggressiveness of such cells. Accordingly, the brain's 'privilege' is its acquisition of a private peripheral immunological niche under its own control, which supports brain function. Immune malfunction may comprise a missing link between a healthy and diseased mind.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.