ArticleCancer prevention research (Philadelphia, Pa.)2010
The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence.
Article in Cancer prevention research (Philadelphia, Pa.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- MicroRNAs in sputum specimen as noninvasive biomarkers for the diagnosis of nonsmall cell lung cancer: An updated meta-analysis.Medicine · 2019Pooled it
- Guideline
- Liquid Biopsy in Lung Cancer: Biomarkers for the Management of Recurrence and Metastasis.International journal of molecular sciences · 2023Review
- Clinical Utility of Chromosomal Aneusomy in Individuals at High Risk of Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2017Article
- Biomarkers of risk to develop lung cancer in the new screening era.Annals of translational medicine · 2016Review
- Convergence of nanotechnology and cancer prevention: are we there yet?Cancer prevention research (Philadelphia, Pa.) · 2014Review
- Identification of ENO1 as a potential sputum biomarker for early-stage lung cancer by shotgun proteomics.Clinical lung cancer · 2014Article
- Analysis of MicroRNAs in sputum to improve computed tomography for lung cancer diagnosis.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2014Article
- Evaluation of lung flute in sputum samples for molecular analysis of lung cancer.Clinical and translational medicine · 2013Article
- Review
- Review
- Surveillance of resected non-small cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2012Review
- Defining a gene promoter methylation signature in sputum for lung cancer risk assessment.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Update on biomarkers for the detection of lung cancer.Lung Cancer (Auckland, N.Z.) · 2012Review
- Progressive endobronchial premalignancy: marked by original CIN.American journal of respiratory and critical care medicine · 2011Article
- Sputum-based molecular biomarkers for the early detection of lung cancer: limitations and promise.Cancers · 2011Article
- [Advances in early diagnosis of lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2011Review
- De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Interphase cytogenetics of sputum cells for the early detection of lung carcinogenesis.Cancer prevention research (Philadelphia, Pa.) · 2010Review
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15 authors at 5 institutions in 1 country.
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Abstract
Lung cancer usually is disseminated (advanced) and has a poor prognosis at diagnosis. Current and former smokers are at a high risk for lung cancer and are candidates for prevention and early detection strategies. Sputum is a potential source of biomarkers that might determine either lung cancer risk or the presence of early lung cancer, but no current sputum test is sufficiently sensitive and specific for effective screening. We used fluorescence in situ hybridization (FISH) to measure chromosomal aneusomy (CA) in sputum samples collected prospectively from 100 incident lung cancer cases and 96 controls (matched on age, gender, and date of collection) nested within an ongoing high-risk cohort. The CA-FISH assay was aimed at four DNA targets: epidermal growth factor receptor, MYC, 5p15, and CEP 6. The sensitivity of a positive CA-FISH assay (abnormal for two or more of the four markers) for lung cancer was substantially higher for samples collected within 18 months (76% sensitivity) than for samples collected more than 18 months (31%) before lung cancer diagnosis. Sensitivity was higher for squamous cell cancers (94%) than for other histologic types (69%). CA-FISH specificity based on samples collected within 18 months before diagnosis was 88%. The adjusted odds ratio (OR) of lung cancer for specimens collected within 18 months before a cancer diagnosis was higher for the CA-FISH assay [OR, 29.9; 95% confidence interval (95% CI), 9.5-94.1] than for previously studied ORs of cytologic atypia (OR, 1.8; 95% CI, 1.3-2.6) and gene promoter methylation (OR, 6.5; 95% CI, 1.2-35.5). Whether CA-FISH is an indicator of extreme risk for incident lung cancer or detects exfoliated cancer cells is unknown. The apparent promise of CA-FISH in sputum for assessing lung cancer risk and/or for lung cancer early detection now needs to be validated in a clinical screening trial.
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