Evidence map›Paper›PMID 20332297›Full record

ReviewCancer prevention research (Philadelphia, Pa.)2010

Vaccine prevention of cancer: can endogenous antigens be targeted?

Louis M Weiner, Rishi Surana, Joseph Murray

Open access · bronzeAbstract readCommentReview
In one paragraph

Review in Cancer prevention research (Philadelphia, Pa.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Nonviral oncogenic antigens and the inflammatory signals driving early cancer development as targets for cancer immunoprevention.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015
    Review
  5. Overexpressed oncogenic tumor-self antigens.Human vaccines & immunotherapeutics · 2014
    Review
  6. Article
  7. What is recent in pancreatic cancer immunotherapy?BioMed research international · 2013
    Review
  8. Future directions in cancer prevention.Nature reviews. Cancer · 2012
    Review
  9. Article
  10. Review
  11. Stimulation of anti-tumor immunity by photodynamic therapy.Expert review of clinical immunology · 2011
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Louis M WeinerLombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road Northwest, Washington, DC 20057, USA. weinerl@georgetown.edu
Rishi Surana
Joseph Murray
Georgetown University · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
TARGETED IMMUNOTHERAPY USING BISPECIFIC ANTIBODIESR01CA050633 · NCI · GEORGETOWN UNIVERSITY · PI WEINER, LOUIS M. · 1989 to 2018
$6.5M
Adaptive Immunity from High Affinity Anti-HER2/neu Monoclonal AntibodiesR01CA121033 · NCI · GEORGETOWN UNIVERSITY · PI WEINER, LOUIS M. · 2006 to 2010
$1.5M
Tumor-based Modulators of Antibody-Dependent Cellular Cytotoxicity (ADCC)F30CA165474 · NCI · GEORGETOWN UNIVERSITY · PI MURRAY, JOSEPH C · 2012 to 2014
$125k
NCI NIH HHS CA121033NCI NIH HHS CA50633NCI NIH HHS CA51008NCI NIH HHS F30 CA165474NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA050633NCI NIH HHS R01 CA121033NCI NIH HHS T32 CA009686
6 · The paper itself

Abstract

This perspective on the report by Beatty et al. in this issue of the journal (beginning on page 438) discusses the prevention of cancer through vaccination strategies that target antigens associated with tumor promotion and progression. Such approaches were first developed for treating cancer. We address cancer vaccination in the context of a mouse model of inflammatory bowel disease expressing MUC1, an epithelial mucin aberrantly expressed during chronic inflammation and in colorectal carcinogenesis, and in a broader context that includes the potential of targeting the tumor microenvironment for immunoprevention in humans. Obstacles in developing effective cancer vaccines, including antigen selection, immunoediting, and tumor-mediated immunosuppression, are also discussed.

Indexed as

AnimalsAntigens, NeoplasmCancer VaccinesHumansNeoplasmsAntigens, NeoplasmCancer Vaccines

Identifiers

PMID20332297
PMCPMC2853240
OpenAlexW2127077454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.