Evidence map›Paper›PMID 20332277›Full record

ReviewCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010

Urine collection and processing for protein biomarker discovery and quantification.

C Eric Thomas, Wade Sexton, Kaaron Benson, Rebecca Sutphen, John Koomen

Abstract readReview
In one paragraph

Review in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Best practices for using biological data in psychological research.Journal of mood and anxiety disorders · 2026
    Review
  4. Article
  5. Application of serum miRNA panel in bladder cancer detection.Translational andrology and urology · 2026
    Article
  6. Metabolomics and Biomarker Discovery.Advances in experimental medicine and biology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Biomarkers of Stress and Inflammation in Children.Biological research for nursing · 2023
    Article
  16. Review
  17. Article
  18. Diagnostic Study to Assess the Performance of a New UrinaryInternational journal of environmental research and public health · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

C Eric ThomasProteomics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Wade Sexton
Kaaron Benson
Rebecca Sutphen
John Koomen

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Population-Based Analysis of Ovarian Cancer BiomarkersR01CA106414 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI SUTPHEN, REBECCA · 2005 to 2009
$3.0M
Quantitative Mass Spectrometry Assays to Detect Multiple Myeloma and Assess RelapR21CA141285 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI KOOMEN, JOHN M · 2009 to 2010
$404k
NCI NIH HHS P30 CA076292NCI NIH HHS P30-CA076292NCI NIH HHS R01 CA106414NCI NIH HHS R01-CA106414NCI NIH HHS R21 CA141285NCI NIH HHS R21-CA141285
6 · The paper itself

Abstract

backgroundUrine is a useful source of protein for biomarker discovery and assessment because it is readily available, can be obtained by noninvasive collection methods, and enables monitoring of a wide range of physiologic processes and diseases. Urine aliquots provide enough protein for multiple analyses, combining current protocols with new techniques.

conclusionsStandardized collection and processing protocols are now being established and new methods for protein detection and quantification are emerging to complement traditional immunoassays. The current state of urine collection, specimen processing, and storage is reviewed with regard to discovery and quantification of protein biomarkers for cancer.

Indexed as

ProteinsBiomarkersHumansProteomicsSpecimen HandlingBiomarkersProteins

Identifiers

PMID20332277
PMCPMC2852495

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.