ArticleBMC systems biology2010
Linking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans.
Article in BMC systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Combined effects of a pyrethroid insecticide and azole fungicide on lepidopteran growth analysed with DEB-TKTD modelling.Ecotoxicology (London, England) · 2025Article
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- A multi-domain snail metallothionein increases cadmium resistance and fitness in Caenorhabditis elegans.Scientific reports · 2024Article
- Mitochondria in the Spotlight:Cells · 2023Review
- Nematodes As Soil Stress Indicators for Polycyclic Aromatic Hydrocarbons: a Review.Helminthologia · 2022Article
- Effect of fluensulfone on different functional genes of root-knot nematodeJournal of nematology · 2021Article
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- A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories.Scientific reports · 2019Article
- Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles inInternational journal of nanomedicine · 2017Article
- Extending standard testing period in honeybees to predict lifespan impacts of pesticides and heavy metals using dynamic energy budget modelling.Scientific reports · 2016Article
- Article
- Experimental studies with nematodes in ecotoxicology: an overview.Journal of nematology · 2015Article
- Gene-environment and protein-degradation signatures characterize genomic and phenotypic diversity in wild Caenorhabditis elegans populations.BMC biology · 2013Article
- Consequences of a multi-generation exposure to uranium on Caenorhabditis elegans life parameters and sensitivity.Ecotoxicology (London, England) · 2013Article
- Towards an understanding of the function of the phytochelatin synthase of Schistosoma mansoni.PLoS neglected tropical diseases · 2013Article
- Article
- The Nematode Caenorhabditis elegans, Stress and Aging: Identifying the Complex Interplay of Genetic Pathways Following the Treatment with Humic Substances.Frontiers in genetics · 2012Article
- Caenorhabditis elegans as a model in developmental toxicology.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Article
- Application of physiologically based modelling and transcriptomics to probe the systems toxicology of aldicarb for Caenorhabditis elegans (Maupas 1900).Ecotoxicology (London, England) · 2011Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene expression following exposure to three toxic chemicals: cadmium, fluoranthene (FA) and atrazine (AZ).
resultsFor Cd, the physiological mode of action as indicated by DEBtox model fitting was an effect on energy assimilation from food, suggesting that the transcriptional response to exposure should be dominated by changes in the expression of transcripts associated with energy metabolism and the mitochondria. While evidence for effect on genes associated with energy production were seen, an ontological analysis also indicated an effect of Cd exposure on DNA integrity and transcriptional activity. DEBtox modelling showed an effect of FA on costs for growth and reproduction (i.e. for production of new and differentiated biomass). The microarray analysis supported this effect, showing an effect of FA on protein integrity and turnover that would be expected to have consequences for rates of somatic growth. For AZ, the physiological mode of action predicted by DEBtox was increased cost for maintenance. The transcriptional analysis demonstrated that this increase resulted from effects on DNA integrity as indicated by changes in the expression of genes chromosomal repair.
conclusionsOur results have established that outputs from process based models and transcriptomics analyses can help to link mechanisms of action of toxic chemicals with resulting demographic effects. Such complimentary analyses can assist in the categorisation of chemicals for risk assessment purposes.
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