ArticleArthritis research & therapy2010
A rational use of glucocorticoids in patients with early arthritis has a minimal impact on bone mass.
Article in Arthritis research & therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Bone mineral density of postmenopausal women with rheumatoid arthritis depends on disease duration regardless of treatment.Journal of bone and mineral metabolism · 2017Trial
- Are changes in bone mineral density different between groups of early rheumatoid arthritis patients treated according to a tight control strategy with or without prednisone if osteoporosis prophylaxis is applied?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Trial
- Vertebral fractures are increased in rheumatoid arthritis despite recent therapeutic advances: a case-control study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Correlation of osteoarthritis or rheumatoid arthritis with bone mineral density in adults aged 20-59 years.Journal of orthopaedic surgery and research · 2021Article
- Osteoporosis in Rheumatoid Arthritis: Dangerous Liaisons.Frontiers in medicine · 2020Review
- A TRAF6 genetic variant is associated with low bone mineral density in rheumatoid arthritis.Clinical rheumatology · 2019Article
- Relationship between bone mineral density and anti-citrullinated protein antibody and rheumatoid factor in patients with rheumatoid arthritis.European journal of rheumatology · 2019Article
- Anti-citrullinated protein antibodies are associated with decreased bone mineral density: baseline data from a register of early arthritis patients.Rheumatology international · 2017Article
- Bone-density testing interval and transition to osteoporosis in patients with rheumatoid arthritis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Observational
- A cross-sectional study to estimate associations between education level and osteoporosis in a Chinese postmenopausal women sample.International journal of clinical and experimental medicine · 2015Article
- Marine Diterpenoids as Potential Anti-Inflammatory Agents.Mediators of inflammation · 2015Review
- Association between rheumatoid arthritics and osteoporosis among Chinese men, a community based study.International journal of clinical and experimental medicine · 2015Article
- Osteoporosis and osteoarthritis, rheumatoid arthritis and spondylarthropathies.Current osteoporosis reports · 2013Review
- Bone mineral density and frequency of osteoporosis among Vietnamese women with early rheumatoid arthritis.Clinical rheumatology · 2011Article
- Interleukin 15 levels in serum may predict a severe disease course in patients with early arthritis.PloS one · 2011Article
- The use of glucocorticoids in rheumatoid arthritis--no 'rational' approach yet.Arthritis research & therapy · 2010Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionGlucocorticoid (GC)-induced osteoporosis is a frequent complication in patients with rheumatoid arthritis. However, little information exists about the consequences of GC use in patients with early arthritis. Here we describe the variables underlying the use of GC in early arthritis, as well as its effect on bone-mineral density.
methodsData from 116 patients in our early arthritis register were analyzed (90 women; median age, 52.5 years, interquartile range (IQR, 38.5-66); 6-month median disease duration at entry (IQR, 4-9)). In this register, the clinical and treatment information was recorded systematically, including the cumulative GC dose. Lumbar spine, hip, and forearm bone-mineral density (BMD) measurements were performed at entry and after a 2-year follow-up. A multivariate analysis was performed to establish the variables associated with the use of GCs, as well as those associated with variations in BMD.
resultsOf the patients with early arthritis studied, 67% received GCs during the 2-year follow-up. GCs were more frequently prescribed to elderly patients, those with higher basal disease activity and disability, and patients with positive rheumatoid factor. When adjusted for these variables, GCs were less frequently prescribed to female patients. The use of GCs was associated with an increase of BMD in the ultradistal region of the forearm, although it induced a significant loss of BMD in the medial region of the forearm. No relevant effect of GC was noted on the BMD measured at other locations.
conclusionsThe frequent use of GCs as a "bridge therapy" in patients with early arthritis does not seem to be associated with relevant loss of bone mass. Moreover, cumulative GC administration might be associated with an increase of juxtaarticular BMD.
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