Trial reportCritical care (London, England)2010
Near-infrared spectroscopy during stagnant ischemia estimates central venous oxygen saturation and mixed venous oxygen saturation discrepancy in patients with severe left heart failure and additional sepsis/septic shock.
Trial report in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Skeletal Muscle Oxygenation in Critically Ill
Cerebral and Skeletal Muscle Oxygenation During Cardiopulmonary Resuscitation as a Predictor of Return of Spontaneous Circulation
Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- "hDOS": an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision andJournal of biomedical optics · 2025Article
- The relationship between trajectories of renal oxygen saturation and acute kidney injury: a prospective cohort study with a secondary analysis.Aging clinical and experimental research · 2024Article
- Skeletal muscle oxygenation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation: a pilot study.European journal of medical research · 2023Article
- Near-infrared spectroscopy of the placenta for monitoring fetal oxygenation during labour.PloS one · 2020Article
- Comparison of two devices using near-infrared spectroscopy for the measurement of tissue oxygenation during a vascular occlusion test in healthy volunteers (INVOS® vs. InSpectra™).Journal of clinical monitoring and computing · 2015Article
- Isoproterenol infusion and microcirculation in septic shock.Heart, lung and vessels · 2014Article
- Skeletal muscle oxygen saturation (StO2) measured by near-infrared spectroscopy in the critically ill patients.BioMed research international · 2013Review
- Initial emergency department diagnosis and management of adult patients with severe sepsis and septic shock.Scandinavian journal of trauma, resuscitation and emergency medicine · 2012Review
- Near infrared spectroscopy (NIRS) of the thenar eminence in anesthesia and intensive care.Annals of intensive care · 2012Article
- Near-infrared spectroscopy for evaluation of global and skeletal muscle tissue oxygenation.World journal of cardiology · 2011Article
- Year in review 2010: Critical Care--Cardiology.Critical care (London, England) · 2011Review
- Tissue saturation measurement--exciting prospects, but standardisation and reference data still needed.Critical care (London, England) · 2010Article
- Can central-venous oxygen saturation be estimated from tissue oxygen saturation during a venous occlusion test?Revista Brasileira de terapia intensivaObservational
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDiscrepancies of 5-24% between superior vena cava oxygen saturation (ScvO2) and mixed venous oxygen saturation (SvO2) have been reported in patients with severe heart failure. Thenar muscle tissue oxygenation (StO2) measured with near-infrared spectroscopy (NIRS) during arterial occlusion testing decreases slower in sepsis/septic shock patients (lower StO2 deoxygenation rate). The StO2 deoxygenation rate is influenced by dobutamine. The aim of this study was to determine the relationship between the StO2 deoxygenation rate and the ScvO2-SvO2 discrepancy in patients with severe left heart failure and additional sepsis/septic shock treated with or without dobutamine.
methodsFifty-two patients with severe left heart failure due to primary heart disease with additional severe sepsis/septic shock were included. SvO2 and ScvO2 were compared to the thenar muscle StO2 before and during arterial occlusion.
resultsSvO2 correlated significantly with ScvO2 (Pearson correlation 0.659, P = 0.001), however, Bland Altman analysis showed a clinically important difference between both variables (ScvO2-SvO2 mean 72 +/- 8%, ScvO2-SvO2 difference 9.4 +/- 7.5%). The ScvO2-SvO2 difference correlated with plasma lactate (Pearson correlation 0.400, P = 0.003) and the StO2 deoxygenation rate (Pearson correlation 0.651, P = 0.001). In the group of patients treated with dobutamine, the ScvO2-SvO2 difference correlated with plasma lactate (Pearson correlation 0.389, P = 0.011) and the StO2 deoxygenation rate (Pearson correlation 0.777, P = 0.0001).
conclusionsIn patients with severe heart failure with additional severe sepsis/septic shock the ScvO2-SvO2 discrepancy presents a clinical problem. In these patients the skeletal muscle StO2 deoxygenation rate is inversely proportional to the difference between ScvO2 and SvO2; dobutamine does not influence this relationship. When using ScvO2 as a treatment goal, the NIRS measurement may prove to be a useful non-invasive diagnostic test to uncover patients with a normal ScvO2 but potentially an abnormally low SvO2.
trial registrationNCT00384644 ClinicalTrials.Gov.
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