ReviewOral diseases2010
Folic acid and orofacial clefts: a review of the evidence.
Review in Oral diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- SNPs in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate, a meta-analysis.Bioscience reports · 2020Pooled it
- Methylenetetrahydrofolate reductase C677T polymorphism is not associated with the risk of nonsyndromic cleft lip/palate: An updated meta-analysis.Scientific reports · 2020Pooled it
- Effects and safety of periconceptional oral folate supplementation for preventing birth defects.The Cochrane database of systematic reviews · 2015Pooled it
- Effects and safety of periconceptional folate supplementation for preventing birth defects.The Cochrane database of systematic reviews · 2010Pooled it
- Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil.Journal of perinatal medicine · 2013Trial
- High dosage folic acid supplementation, oral cleft recurrence and fetal growth.International journal of environmental research and public health · 2013Trial
- Multiple congenital malformations in a litter of feline fetuses associated with gestational exposure to a synthetic estrus-suppressing progestin.BMC veterinary research · 2026Article
- DNA methylation as a biomarker of prenatal exposures: current challenges and opportunities.Environmental epigenetics · 2026Review
- Impact of maternal body mass index and gestational comorbidities on the birth prevalence of orofacial clefts in the Japan Environment and Children's Study.Environmental health and preventive medicine · 2025Article
- Article
- Epidemiology of cleft lip and palate in Bhutan, 2015-2022.BMC oral health · 2024Article
- Orofacial Clefts and Maternal Risk Factors: A Population-Based Case-Control Study.Children (Basel, Switzerland) · 2024Article
- Protective effect ofNagoya journal of medical science · 2024Article
- History of Eugenics in Otorhinolaryngology: Ernst Rüdin and the International Eugenics Network.International archives of otorhinolaryngology · 2024Article
- Before Is Better: Innovative Multidisciplinary Preconception Care in Different Clinical Contexts.Journal of clinical medicine · 2023Review
- The roles of JAK2/STAT3 signaling in fusion of the secondary palate.Disease models & mechanisms · 2023Article
- Review
- Smith-Lemli-Opitz syndrome: A pathophysiological manifestation of the Bloch hypothesis.Frontiers in molecular biosciences · 2023Review
- Academic outcomes of children with orofacial clefts: A review of the literature and recommendations for future research.Oral diseases · 2022Review
- Folate Carrier Deficiency Drives Differential Methylation and Enhanced Cellular Potency in the Neural Plate Border.Frontiers in cell and developmental biology · 2022Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Orofacial clefts are common and burdensome birth defects with a complex genetic and environmental etiology. The contribution of nutritional factors and supplements to the etiology of orofacial clefts has long been theorized and studied. Multiple studies have evaluated the role of folic acid in the occurrence and recurrence of orofacial clefts, using observational and non-randomized interventional designs. While preventive effects of folic acid on orofacial clefts are commonly reported, the evidence remains generally inconsistent. This paper reviews the findings of the main studies of the effects of folic acid on orofacial clefts, summarizes study limitations, and discusses research needs with a focus on studying the effects of high dosage folic acid on the recurrence of oral clefts using a randomized clinical trial design. The role of folic acid in the prevention of neural tube defects is also briefly summarized and discussed as a reference model for orofacial clefts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.