ArticleBrain pathology (Zurich, Switzerland)2010
Neuropathological findings in intractable epilepsy: 435 Chinese cases.
Article in Brain pathology (Zurich, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- [BMC neurology · 2026Article
- MRI-based radiomics model for differentiating focal cortical dysplasia from dysembryoplastic neuroepithelial tumor in epileptic children.Frontiers in neurology · 2025Article
- [Analysis of neural fragility in epileptic zone based on stereoelectroencephalography].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy.Brain sciences · 2022Article
- Anterior transtemporal endoscopic selective amygdalohippocampectomy: a virtual and cadaveric feasibility study.Acta neurochirurgica · 2022Article
- Integrated genotype-phenotype analysis of long-term epilepsy-associated ganglioglioma.Brain pathology (Zurich, Switzerland) · 2022Article
- Case Report: Late-Onset Lennox-Gastaut Syndrome Treated With Stereotactic Electroencephalography-Guided Radiofrequency Thermocoagulation Before Craniotomy.Frontiers in neurology · 2022Article
- Surgical histopathologic findings of 232 Chinese children cases with drug-resistant seizures.Brain and behavior · 2020Article
- Distinguishing Focal Cortical Dysplasia From Glioneuronal Tumors in Patients With Epilepsy by Machine Learning.Frontiers in neurology · 2020Article
- Use of an Automated Quantitative Analysis of Hippocampal Volume, Signal, and Glucose Metabolism to Detect Hippocampal Sclerosis.Frontiers in neurology · 2018Article
- Intractable Epilepsy with Solitary Cerebral Calcification.Journal of epilepsy research · 2017Article
- Detection superiority of 7 T MRI protocol in patients with epilepsy and suspected focal cortical dysplasia.Acta neurologica Belgica · 2016Article
- Comparisons of MR Findings Between Supratentorial and Infratentorial Gangliogliomas.Clinical neuroradiology · 2016Article
- Dysembryoplastic Neuroepithelial Tumors.Journal of pathology and translational medicine · 2015Review
- Expression Patterns of TRPC1 in Cortical Lesions from Patients with Focal Cortical Dysplasia.Journal of molecular neuroscience : MN · 2015Article
- Upregulation of RBFOX1 in the malformed cortex of patients with intractable epilepsy and in cultured rat neurons.International journal of molecular medicine · 2015Article
- A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors.Acta neuropathologica · 2014Review
- Down-regulated expression of acid-sensing ion channel 1a in cortical lesions of patients with focal cortical dysplasia.Journal of molecular neuroscience : MN · 2014Article
- Factors associated with preoperative and postoperative epileptic seizure in patients with cerebral ganglioglioma.Pakistan journal of medical sciences · 2014Article
- Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature.Oncology letters · 2013Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of patients with intractable epilepsy undergoing surgical management in China is increasing rapidly. We retrospectively reviewed 435 consecutive cases of intractable epilepsy receiving surgical resection from 2005 to 2008 in our hospital, looking specifically at the neuropathological findings. The three most common causes of intractable epilepsy were focal cortical dysplasia (FCD; 52.9%), scar lesions (22.8%) and brain tumors (11.7%). Hippocampal sclerosis was identified in 74 cases (17.0%), although most of these were accompanied by dual pathology with FCD (especially Palmini type IB), scar lesions or tumors. Among FCD cases, Palmini type I lesions are the most frequently observed abnormality, with a preferred location in the temporal lobe (60.1%) and often accompanied by dual pathology. In contrast, Palmini type II FCD lesions occurred predominantly in the frontal regions and with a lower age of onset. Most tumors were mixed neuronal-glial tumors, mainly ganglioglioma (19 cases) and dysembryoplastic neuroepithelial tumor (10 cases), with a trend toward a temporal location and usually accompanied by cortical dysplasia in the peritumor area. Our data on the neuropathology of intractable epilepsy in China show that glioneuronal lesions are the most prominent cause of intractable epilepsy, and this is consistent with reports from other countries.
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