ArticleAddiction (Abingdon, England)2010
Methadone maintenance therapy promotes initiation of antiretroviral therapy among injection drug users.
Article in Addiction (Abingdon, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
96 citing papers in PubMed, 7 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Pooled it
- A client-centered relational framework on barriers to the integration of HIV and substance use services: a systematic review.Harm reduction journal · 2019Pooled it
- Systematic review of HIV treatment adherence research among people who inject drugs in the United States and Canada: evidence to inform pre-exposure prophylaxis (PrEP) adherence interventions.BMC public health · 2019Pooled it
- Integrated opioid substitution therapy and HIV care: a qualitative systematic review and synthesis of client and provider experiences.AIDS care · 2017Pooled it
- The paradigm of universal access to HIV-treatment and human rights violation: how do we treat HIV-positive people who use drugs?Current HIV/AIDS reports · 2014Pooled it
- Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel.Annals of internal medicine · 2012Guideline
- Guideline
- HIV-Related Stigma, Motivation to Adhere to Antiretroviral Therapy, and Medication Adherence Among HIV-Positive Methadone-Maintained Patients.Journal of acquired immune deficiency syndromes (1999) · 2019Trial
- The impact of methadone maintenance therapy on access to regular physician care regarding hepatitis C among people who inject drugs.PloS one · 2018Trial
- Trial
- Expanding substance use treatment options for HIV prevention with buprenorphine-naloxone: HIV Prevention Trials Network 058.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Integration of health services improves multiple healthcare outcomes among HIV-infected people who inject drugs in Ukraine.Drug and alcohol dependence · 2014Trial
- Directly observed antiretroviral therapy eliminates adverse effects of active drug use on adherence.Drug and alcohol dependence · 2012Trial
- Considerations when prescribing opioid agonist therapies for people living with HIV.Expert review of clinical pharmacology · 2024Review
- Factors associated with 60-day adherence to "safer supply" opioids prescribed under British Columbia's interim clinical guidance for health care providers to support people who use drugs during COVID-19 and the ongoing overdose emergency.The International journal on drug policy · 2022Article
- Participation in methadone programs improves antiretroviral uptake and HIV viral suppression among people who inject drugs in Kenya.Journal of substance abuse treatment · 2022Article
- Lessons from the First Wave of COVID-19 for Improved Medications for Opioid Use Disorder (MOUD) Treatment: Benefits of Easier Access, Extended Take Homes, and New Delivery Modalities.Substance use & misuse · 2022Article
- Pre-exposure prophylaxis awareness, acceptability and potential stigma among medical and non-medical clinic staff in methadone treatment settings in northern New Jersey: The key role of non-medical staff in enhancing HIV prevention.Journal of substance abuse treatment · 2021Article
- A Systematic Review and Meta-Analysis of Studies Evaluating the Effect of Medication Treatment for Opioid Use Disorder on Infectious Disease Outcomes.Open forum infectious diseases · 2021Review
- A chance to do it better: Methadone maintenance treatment in the age of Covid-19.Journal of substance abuse treatment · 2021Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
aimsDespite proven benefits of antiretroviral therapy (ART), many human immunodeficiency virus (HIV)-infected injection drug users (IDU) do not access treatment even in settings with free health care. We examined whether methadone maintenance therapy (MMT) increased initiation and adherence to ART among an IDU population with free health care.
designWe examined prospectively a cohort of opioid-using antiretroviral-naive HIV-infected IDU and investigated factors associated with initiation of antiretroviral therapy as well as subsequent adherence. Factors associated independently with time to first initiation of antiretroviral therapy were modelled using Cox proportional hazards regression.
findingsBetween May 1996 and April 2008, 231 antiretroviral-naive HIV-infected opioid-using IDU were enrolled, among whom 152 (65.8%) initiated ART, for an incidence density of 30.5 [95% confidence interval (CI): 25.9-35.6] per 100 person-years. After adjustment for time-updated clinical characteristics and other potential confounders, use of MMT was associated independently with more rapid uptake of antiretroviral therapy [relative hazard = 1.62 (95% CI: 1.15-2.28); P = 0.006]. Those prescribed methadone also had higher rates of ART adherence after first antiretroviral initiation [odds ratio = 1.49 (95% CI: 1.07-2.08); P = 0.019].
conclusionThese results demonstrate that MMT contributes to more rapid initiation and subsequent adherence to ART among opioid-using HIV-infected IDU. Addressing international barriers to the use and availability of methadone may increase dramatically uptake of HIV treatment among this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.