ArticleJournal of insect science (Online)2007
Phagocytosis of the Lyme disease spirochete, Borrelia burgdorferi, by cells from the ticks, Ixodes scapularis and Dermacentor andersoni, infected with an endosymbiont, Rickettsia peacockii.
Article in Journal of insect science (Online), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Use of Tick Cell Lines in Co-Infection Studies with a Preliminary Study of Co-Culture ofPathogens (Basel, Switzerland) · 2025Article
- Croquemort elicits activation of the immune deficiency pathway in ticks.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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- The Novel Zoonotic Pathogen,Pathogens (Basel, Switzerland) · 2021Article
- Pathogenic effects of inhibition of mTORC1/STAT3 axis facilitates Staphylococcus aureus-induced pyroptosis in human macrophages.Cell communication and signaling : CCS · 2020Article
- Francisella tularensis novicida infection competence differs in cell lines derived from United States populations of Dermacentor andersoni and Ixodes scapularis.Scientific reports · 2018Article
- Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission ofFrontiers in cellular and infection microbiology · 2017Article
- Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector.Cell host & microbe · 2016Article
- Fluorescent membrane markers elucidate the association of Borrelia burgdorferi with tick cell lines.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- An Ixodes scapularis cell line with a predominantly neuron-like phenotype.Experimental & applied acarology · 2015Article
- Identification of host proteins involved in rickettsial invasion of tick cells.Infection and immunity · 2015Article
- Coinfection of tick cell lines has variable effects on replication of intracellular bacterial and viral pathogens.Ticks and tick-borne diseases · 2014Article
- Immunity-related genes in Ixodes scapularis--perspectives from genome information.Frontiers in cellular and infection microbiology · 2014Review
- Tick cell culture isolation and growth of Rickettsia raoultii from Dutch Dermacentor reticulatus ticks.Ticks and tick-borne diseases · 2012Article
- Expression patterns of Anaplasma marginale Msp2 variants change in response to growth in cattle, and tick cells versus mammalian cells.PloS one · 2012Article
- Infection and replication of Bartonella species within a tick cell line.Experimental & applied acarology · 2009Article
- Transgene expression and silencing in a tick cell line: A model system for functional tick genomics.Insect biochemistry and molecular biology · 2008Article
- Symbiont-mediated protection.Proceedings. Biological sciences · 2008Review
- Rickettsia peacockii, an endosymbiont of Dermacentor andersoni, does not elicit or inhibit humoral immune responses from immunocompetent D. andersoni or Ixodes scapularis cell lines.Developmental and comparative immunology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tick cell lines were used to model the effects of endosymbiont infection on phagocytic immune responses. The lines tested for their ability to phagocytose the Lyme disease spirochete, Borrelia burgdorferi (Spirochaetales: Spirochaetaceae), were ISE6 and IDE12 from the black-legged tick, Ixodes scapularis Say (Acari: Ixodidae) and DAE15 from the Rocky Mountain wood tick, Dermacentor andersoni Stiles. Rickettsia peacockii (Rickettsiales: Rickettsiaceae), an endosymbiont of D. andersoni, was used as a representative tick endosymbiont. 70-80% of uninfected or R. peacocciz-infected IDE12 and DAE15 cells phagocytosed heat-killed borreliae and 80-90% of IDE12 and DAE15 cells phagocytosed viable spirochetes. ISE6 cells were permissive of spirochetes; less than 1% of these cells phagocytosed borreliae, and spirochetes remained adherent to the cells seven days after inoculation. Cytochalasin B blocked phagocytosis of killed and viable borreliae by IDE12 cells, and prevented phagocytosis of killed spirochetes by DAE15 cells, whereas viable spirochetes successfully invaded cytochalasin-treated DAE15. IDE12 and DAE15 cells degraded borreliae within phagolysosome-like compartments. Time-lapse microscopy showed that DAE15 cells phagocytosed borreliae more rapidly than IDE12 cells. IDE12 and DAE15 cells eliminated most adherent spirochetes within 7 days of inoculation. Thus, endosymbiont infection does not significantly interfere with the phagocytic activity of immunocompetent tick cells.
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