ArticleThe Journal of infectious diseases2010
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Molecular Basis for the Differential Function of HAVCR1 Mucin Variants.Biomedicines · 2024Article
- TANK Promotes Pressure Overload Induced Cardiac HypertrophyFrontiers in cardiovascular medicine · 2021Article
- HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules.Scientific reports · 2019Article
- Determinants in the Ig Variable Domain of Human HAVCR1 (TIM-1) Are Required To Enhance Hepatitis C Virus Entry.Journal of virology · 2018Article
- Global Inequities in Precision Medicine and Molecular Cancer Research.Frontiers in oncology · 2018Review
- Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.Scientific reports · 2017Article
- TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection.Journal of virology · 2017Article
- Identification of the transcripts associated with spontaneous HCV clearance in individuals co-infected with HIV and HCV.BMC infectious diseases · 2016Article
- Polymorphisms in EGFR and IL28B are associated with spontaneous clearance in an HCV-infected Iranian population.Genes and immunity · 2015Article
- Polymorphisms near the IFNL3 Gene Associated with HCV RNA Spontaneous Clearance and Hepatocellular Carcinoma Risk.Scientific reports · 2015Article
- Favourable IFNL3 genotypes are associated with spontaneous clearance and are differentially distributed in Aboriginals in Canadian HIV-hepatitis C co-infected individuals.International journal of molecular sciences · 2015Article
- Advanced molecular surveillance of hepatitis C virus.Viruses · 2015Review
- Association of cytokine gene polymorphisms with hepatitis C virus infection in a population from Rio de Janeiro, Brazil.Hepatic medicine : evidence and research · 2015Article
- Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Review
- Admixture analysis of spontaneous hepatitis C virus clearance in individuals of African descent.Genes and immunity · 2014Article
- Variants in HAVCR1 gene region contribute to hepatitis C persistence in African Americans.The Journal of infectious diseases · 2014Article
- Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study.BMC infectious diseases · 2014Article
- Novel host genetic variations associated with spontaneous clearance of a single-source outbreak of HCV1b infections.BMJ open gastroenterology · 2014Article
- Association of low-density lipoprotein receptor genotypes with hepatitis C viral load.Genes and immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
Human genetic variation is a determinant of recovery from acute hepatitis C virus (HCV) infection; however, to date, single-nucleotide polymorphisms (SNPs) in only a limited number of genes have been studied with respect to HCV clearance. We determined whether SNPs in 112 selected immune response genes are important for HCV clearance, by genotyping 1536 SNPs in a cohort of 343 persons with natural HCV clearance and 547 persons with HCV persistence. PLINK (version 1.05) and Haploview (version 4.1) software packages were used to perform association, permutation, and haplotype analyses stratified by African American and European American race. Of the 1536 SNPs tested, 1426 (92.8%) were successfully genotyped. In African Americans, we identified 18 SNPs located in 11 gene regions that were associated with HCV infection outcome (empirical P value, < .01). In European Americans, there were 20 SNPs located in 8 gene regions associated with HCV infection outcome. Four of the gene regions studied (TNFSF18, TANK, HAVCR1, and IL18BP) contained SNPs for which the empirical P value was <.01 in both of the race groups. In this large-scale analysis of 1426 genotyped SNPs in 112 candidate genes, we identified 4 gene regions that are likely candidates for a role in HCV clearance or persistence in both African Americans and European Americans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.