ArticleAmerican journal of physical anthropology2010
Functional significance of genetic variation underlying limb bone diaphyseal structure.
Article in American journal of physical anthropology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 57 citations in OpenAlex.
- Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior.PloS one · 2024Article
- Multiple solutions at the genomic level in response to selective breeding for high locomotor activity.Genetics · 2023Article
- Ape femoral-humeral rigidities and arboreal locomotion.American journal of biological anthropology · 2022Article
- Article
- Effects of selective breeding for voluntary exercise, chronic exercise, and their interaction on muscle attachment site morphology in house mice.Journal of anatomy · 2022Article
- Rapid and longer-term effects of selective breeding for voluntary exercise behavior on skeletal morphology in house mice.Journal of anatomy · 2021Article
- Effects of selective breeding for high voluntary wheel-running behavior on femoral nutrient canal size and abundance in house mice.Journal of anatomy · 2018Article
- Predicting the bending properties of long bones: Insights from an experimental mouse model.American journal of physical anthropology · 2018Article
- Femoral ontogeny in humans and great apes and its implications for their last common ancestor.Scientific reports · 2018Article
- Bone up: craniomandibular development and hard-tissue biomineralization in neonate mice.Zoology (Jena, Germany) · 2017Article
- Physical activity alters limb bone structure but not entheseal morphology.Journal of human evolution · 2017Article
- Article
- Unique suites of trabecular bone features characterize locomotor behavior in human and non-human anthropoid primates.PloS one · 2012Article
- Identification of quantitative trait loci influencing skeletal architecture in mice: emergence of Cdh11 as a primary candidate gene regulating femoral morphology.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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Abstract
Limb bone diaphyseal structure is frequently used to infer hominin activity levels from skeletal remains, an approach based on the well-documented ability of bone to adjust to its loading environment during life. However, diaphyseal structure is also determined in part by genetic factors. This study investigates the possibility that genetic variation underlying diaphyseal structure is influenced by the activity levels of ancestral populations and might also have functional significance in an evolutionary context. We adopted an experimental evolution approach and tested for differences in femoral diaphyseal structure in 1-week-old mice from a line that had been artificially selected (45 generations) for high voluntary wheel running and non-selected controls. As adults, selected mice are significantly more active on wheels and in home cages, and have thicker diaphyses. Structural differences at 1 week can be assumed to primarily reflect the effects of selective breeding rather than direct mechanical stimuli, given that the onset of locomotion in mice is shortly after Day 7. We hypothesized that if genetically determined diaphyseal structure reflects the activity patterns of members of a lineage, then selected animals will have relatively larger diaphyseal dimensions at 1 week compared to controls. The results provide strong support for this hypothesis and suggest that limb bone cross sections may not always only reflect the activity levels of particular fossil individuals, but also convey an evolutionary signal providing information about hominin activity in the past.
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