ArticleMovement disorders : official journal of the Movement Disorder Society2010
Depression and the subsequent risk of Parkinson's disease in the NIH-AARP Diet and Health Study.
Article in Movement disorders : official journal of the Movement Disorder Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Parkinson's Disease is Associated with Dysregulations of a Dopamine-Modulated Gene Network Relevant to Sleep and Affective Neurobehaviors in the Striatum.Scientific reports · 2019Pooled it
- Hyposmia as a Predictive Marker of Parkinson's Disease: A Systematic Review and Meta-Analysis.BioMed research international · 2019Pooled it
- Parkinson's disease in real life healthcare organization database: a medication-based algorithm.BMC neurology · 2026Article
- Depression and incidence of inflammation-related physical health conditions: a cohort study in UK Biobank.BMC psychiatry · 2025Article
- Relationship Between Depression and Neurodegeneration: Risk Factor, Prodrome, Consequence, or Something Else? A Scoping Review.Biomedicines · 2025Review
- Prodromal Parkinson's disease and subsequent risk of Parkinson's disease and mortality.NPJ Parkinson's disease · 2025Article
- Different risks of early-onset and late-onset Parkinson disease in individuals with mental illness.NPJ Parkinson's disease · 2024Article
- Could the Urease of the Gut BacteriumMicroorganisms · 2023Article
- Screening and Targeting Risk Factors for Prodromal Synucleinopathy: Taking Steps toward a Prescriptive Multi-modal Framework.Aging and disease · 2023Review
- Depression in Patients with Parkinson's Disease: Current Understanding of its Neurobiology and Implications for Treatment.Drugs & aging · 2022Review
- Dose-Response Association of Metformin with Parkinson's Disease Odds in Type 2 Diabetes Mellitus.Pharmaceutics · 2022Article
- Article
- Trend of recognizing depression symptoms and antidepressants use in newly diagnosed Parkinson's disease: Population-based study.Brain and behavior · 2021Article
- Investigating the Convergent Mechanisms between Major Depressive Disorder and Parkinson's Disease.Complex psychiatry · 2021Review
- Management of psychiatric disorders in Parkinson's disease : Neurotherapeutics - Movement Disorders Therapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Depression Comorbid With Stroke, Traumatic Brain Injury, Parkinson's Disease, and Multiple Sclerosis: Diagnosis and Treatment.Focus (American Psychiatric Publishing) · 2020Article
- Comorbid neuropsychiatric and autonomic features in REM sleep behavior disorder.Clinical parkinsonism & related disorders · 2020Article
- The Neuropsychiatry of Parkinson Disease: A Perfect Storm.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Review
- Neuropsychiatric aspects of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Early and Accurate Identification of Parkinson Disease Among US Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
We conducted a case-control study to examine the association between depression and Parkinson's disease (PD). Participants included 992 PD cases diagnosed after 2,000 and 279,958 individuals without PD from the NIH-AARP Diet and Health Study follow-up survey. Physician-diagnosed depression and PD were self-reported with information on the year of diagnosis in the following categories: before 1985, 1985-1994, 1995-1999, and 2000-present. Only PD cases diagnosed after 2000 were included in the analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were derived from logistic regression models, adjusted for age, gender, educational level, marital status, smoking, and coffee drinking. Individuals with depression diagnosed after 2000 were more likely to report a concurrent diagnosis of PD than those without depression (OR = 4.7, 95% CI = 3.9, 5.7). Depression diagnosed before 2000 was also associated with higher odds of PD diagnosed after 2000 (OR = 2.0, 95% CI = 1.6, 2.4). This association was stronger for depression diagnosed in 1995-1999 (OR = 2.7, 95% CI = 2.0, 3.6), but was also noted for depression diagnosed in 1985-1994 (OR = 1.6, 95% CI = 1.1, 2.3) or even before 1985 (OR = 1.7, 95% CI = 1.3, 2.3). This association was not modified by other factors and persisted in an analysis excluding participants who reported poor health status. The results suggest that depression may either be a very early symptom of PD or share common etiological factors with PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.