Evidence map›Paper›PMID 20309880›Full record

ArticleInternational journal of cancer2011

Prognostic significance of differentially expressed miRNAs in esophageal cancer.

Yuxin Hu, Arlene M Correa, Ashraful Hoque, Baoxiang Guan, Fei Ye, Jie Huang, Stephen G Swisher, Tsung Teh Wu, Jaffer A Ajani, Xiao-Chun Xu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 12 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 12 syntheses or guidelines pooled it, 183 citations in OpenAlex.

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  5. Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis.Clinical and translational gastroenterology · 2018
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yuxin HuDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX77030, USA.
Arlene M Correa
Ashraful Hoque
Baoxiang Guan
Fei Ye
Jie Huang
Stephen G Swisher
Tsung Teh Wu
Jaffer A Ajani
Xiao-Chun Xu
The University of Texas MD Anderson Cancer Center · USMayo Clinic in Arizona · US

Funding

Identification of miRNAs as biomarkers in esophageal cancerR03CA123568 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI XU, XIAOCHUN · 2006 to 2007
$148k
NCI NIH HHS R03 CA123568NCI NIH HHS R03CA123568
6 · The paper itself

Abstract

Altered microRNA (miRNA) expression has been found to promote carcinogenesis, but little is known about the role of miRNAs in esophageal cancer. In this study, we selected 10 miRNAs and analyzed their expression in 10 esophageal cancer cell lines and 158 tissue specimens using Northern blotting and in situ hybridization, respectively. We found that Let-7g, miR-21 and miR-195p were expressed in all 10 cell lines, miR-9 and miR-20a were not expressed in any of the cell lines, and miR-16-2, miR-30e, miR-34a, miR-126 and miR-200a were expressed in some of the cell lines but not others. In addition, transient transfection of miR-34a inhibited c-Met and cyclin D1 expression and esophageal cancer cell proliferation, whereas miR-16-2 suppressed RAR-β(2) expression and increased tumor cell proliferation. Furthermore, we found that miR-126 expression was associated with tumor cell dedifferentiation and lymph node metastasis, miR-16-2 was associated with lymph node metastasis, and miR-195p was associated with higher pathologic disease stages in patients with esophageal adenocarcinoma. Kaplan-Meier analysis showed that miR-16-2 expression and miR-30e expression were associated with shorter overall and disease-free survival in all esophageal cancer patients. In addition, miR-16-2, miR-30e and miR-200a expression were associated with shorter overall and disease-free survival in patients with esophageal adenocarcinoma; however, miR-16-2, miR-30e and miR-200a expression were not associated with overall or disease-free survival in squamous cell carcinoma patients. Our data indicate that further evaluation of miR-30e and miR-16-2 as prognostic biomarkers is warranted in patients with esophageal adenocarcinoma. In addition, the role of miR-34a in esophageal cancer also warrants further study.

Indexed as

Gene Expression ProfilingGene Expression Regulation, NeoplasticAdenocarcinomaAdultAgedAged, 80 and overBlotting, NorthernCarcinoma, Squamous CellCell Line, TumorEsophageal NeoplasmsFemaleHumansImmunohistochemistryIn Situ HybridizationKaplan-Meier EstimateKi-67 AntigenKi-67 AntigenMicroRNAsMIRN16 microRNA, humanMIRN30b microRNA, humanMIRN34 microRNA, human

Identifiers

PMID20309880
PMCPMC2937084
OpenAlexW2117298137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.