ArticleCellular and molecular life sciences : CMLS2010
NF-E2-related factor 2, a key inducer of antioxidant defenses, negatively regulates the CFTR transcription.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Role of Nrf2 in Epilepsy Treatment.Current molecular medicine · 2025Review
- Review
- Sinomenine pretreatment alleviates hepatic ischemia/reperfusion injury through activating Nrf-2/HO-1 pathway.Immunity, inflammation and disease · 2022Article
- An Overview of the Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases.International journal of molecular sciences · 2021Review
- [Procyanidin B2 protects neurons from cypermethrin-induced oxidative stress through the P13K/Akt/Nrf2 signaling pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation.Experimental neurology · 2020Review
- Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Human Lung Microvascular Endothelial Cells Controls Oxidative Stress, Reactive Oxygen-Mediated Cell Signaling and Inflammatory Responses.Frontiers in physiology · 2020Article
- [Cypermethrin induces cell injury in primary cortical neurons of C57BL/6 mice by inhibiting Nrf2/ARE signaling pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Therapeutic Approaches to Alzheimer's Disease Through Modulation of NRF2.Neuromolecular medicine · 2019Review
- Dissecting the Keap1/Nrf2 pathway through proteomics.Current opinion in toxicology · 2016Article
- Small-scale high-throughput sequencing-based identification of new therapeutic tools in cystic fibrosis.Genetics in medicine : official journal of the American College of Medical Genetics · 2015Article
- Oxidative stress regulates CFTR gene expression in human airway epithelial cells through a distal antioxidant response element.American journal of respiratory cell and molecular biology · 2015Article
- Phosphorylated C/EBPβ influences a complex network involving YY1 and USF2 in lung epithelial cells.PloS one · 2013Article
- Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2.Biochemical pharmacology · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A few studies have clearly indicated that oxidative stress suppresses the cystic fibrosis transmembrane conductance receptor (CFTR) function and expression. However, the mechanisms by which this occurs are still poorly understood. To clarify this effect, we investigated the role of NF-E2-related factor 2 (Nrf2) transcription factor, a key cellular sensor of oxidative stress. A conserved antioxidant response element (ARE) in the CFTR minimal promoter, which binds Nrf2, has been identified. Surprisingly, Nrf2 exerts an unexpected repressive role on the CFTR gene promoter activity. To decipher the molecular mechanisms involved, we evaluated the role of YY1 in the Nrf2-mediated transcriptional activity and showed cooperation between these two factors. We demonstrated that Nrf2 promotes YY1 nuclear localization and increases its binding to the CFTR promoter. To our knowledge, this study is the first to report a repressor role of Nrf2 through the cooperation with YY1 and contributes to clarify the cascade events leading to the oxidative stress-suppressed CFTR expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.