ArticleEuropean radiology2010
3D 23Na MRI of human skeletal muscle at 7 Tesla: initial experience.
Article in European radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Atrophy of calf muscles by unloading results in an increase of tissue sodium concentration and fat fraction decrease: aEuropean journal of applied physiology · 2017Trial
- Rapid Quantitative Assessment of Muscle Sodium Dynamics After Exercise UsingJournal of cachexia, sarcopenia and muscle · 2025Article
- A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle NaEuropean journal of applied physiology · 2024Review
- Review
- Muscle sodium content in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Journal of translational medicine · 2022Article
- In vivo electrical conductivity measurement of muscle, cartilage, and peripheral nerve around knee joint using MR-electrical properties tomography.Scientific reports · 2022Article
- 7 Tesla and Beyond: Advanced Methods and Clinical Applications in Magnetic Resonance Imaging.Investigative radiology · 2021Review
- Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging.Journal of magnetic resonance imaging : JMRI · 2021Review
- Musculoskeletal MR Imaging Applications at Ultra-High (7T) Field Strength.Magnetic resonance imaging clinics of North America · 2021Review
- Review
- Quantitative techniques for musculoskeletal MRI at 7 Tesla.Quantitative imaging in medicine and surgery · 2016Review
- Quantitative sodium magnetic resonance imaging of cartilage, muscle, and tendon.Quantitative imaging in medicine and surgery · 2016Review
- 23Na Magnetic Resonance Imaging of the Lower Leg of Acute Heart Failure Patients during Diuretic Treatment.PloS one · 2015Article
- Sodium MRI: methods and applications.Progress in nuclear magnetic resonance spectroscopy · 2014Review
- Biomedical applications of sodium MRI in vivo.Journal of magnetic resonance imaging : JMRI · 2013Review
- Permanent muscular sodium overload and persistent muscle edema in Duchenne muscular dystrophy: a possible contributor of progressive muscle degeneration.Journal of neurology · 2012Article
- Review. The Agfa Mayneord lecture: MRI of short and ultrashort T₂ and T₂* components of tissues, fluids and materials using clinical systems.The British journal of radiology · 2011Article
- Functional imaging in muscular diseases.Insights into imaging · 2011Article
- Recent advances in medical physics.European radiology · 2011Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo evaluate healthy skeletal muscle pre- and post-exercise via 7 T (23)Na MRI and muscle proton T(2) mapping, and to evaluate diabetic muscle pre- and post-exercise via 7 T (23)Na MRI.
methodsThe calves of seven healthy subjects underwent imaging pre- and post-exercise via 7 T (23)Na MRI (3D fast low angle shot, TR/TE = 80 ms/0.160 ms, 4 mm x 4 mm x 4 mm) and 1 week later by (1)H MRI (multiple spin-echo sequence, TR/TE = 3,000 ms/15-90 ms). Four type 2 diabetics also participated in the (23)Na MRI protocol. Pre- and post-exercise sodium signal intensity (SI) and proton T(2) relaxation values were measured/calculated for soleus (S), gastrocnemius (G), and a control, tibialis anterior (TA). Two-tailed t tests were performed.
resultsIn S/G in healthy subjects post-exercise, sodium SI increased 8-13% (p < 0.03), then decreased (t(1/2) = 22 min), and (1)H T(2) values increased 12-17% (p < 0.03), then decreased (t(1/2 )= 12-15 min). In TA, no significant changes in sodium SI or (1)H T(2) values were seen (-2.4 to 1%, p > 0.17). In S/G in diabetics, sodium SI increased 10-11% (p < 0.04), then decreased (t(1/2) = 27-37 min) without significant change in the TA SI (-3.6%, p = 0.066).
conclusionIt is feasible to evaluate skeletal muscle via 3D (23)Na MRI at 7 T. Post-exercise muscle (1)H T(2) values return to baseline more rapidly than sodium SI. Diabetics may demonstrate delayed muscle sodium SI recovery compared with healthy subjects.
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