ArticleInternational journal of medical sciences2010
Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis.
Article in International journal of medical sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2015Pooled it
- A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview.Multiple sclerosis (Houndmills, Basingstoke, England) · 2015Pooled it
- Review
- Gastrointestinal conditions in the multiple sclerosis prodrome.Annals of clinical and translational neurology · 2024Article
- Autonomic nervous system disorders in multiple sclerosis.Journal of neurology · 2023Review
- Association of multiple sclerosis with chronic fatigue syndrome, restless legs syndrome, and various sleep disorders, along with the recent updates.Annals of medicine and surgery (2012) · 2023Article
- Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) with postural orthostatic tachycardia syndrome after silicone breast implantation: Case report.European journal of rheumatology · 2023Article
- Autonomic Nervous System Function in Newly Diagnosed Multiple Sclerosis: Association With Lipid Levels and Insulin Resistance.Physiological research · 2021Article
- Management of Postural Orthostatic Tachycardia Syndrome in the Absence of Randomized Controlled Trials.The Journal of innovations in cardiac rhythm management · 2021Article
- Autonomic dysfunctions in multiple sclerosis: Challenges of clinical practice (Review).Experimental and therapeutic medicine · 2020Review
- Evaluation of cardiovascular autonomic dysfunction according to heart rate turbulence and variability in patients with relapsing remitting multiple sclerosisTurkish journal of medical sciences · 2020Article
- Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies.Journal of clinical medicine · 2020Review
- Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis.Frontiers in neurology · 2019Article
- Brugada Syndrome Caused by Autonomic Dysfunction in Multiple Sclerosis.Case reports in cardiology · 2019Article
- Editorial: Autonomic Neuropathy and Cardiovascular Disease in Aging.The journal of nutrition, health & aging · 2018Article
- From Postural Orthostatic Tachycardia Syndrome to Radiologically Isolated Syndrome.Case reports in neurological medicine · 2018Article
- Article
- Autonomic neuropathy-in its many guises-as the initial manifestation of the antiphospholipid syndrome.Immunologic research · 2017Article
- Subjective Cognitive Fatigue and Autonomic Abnormalities in Multiple Sclerosis Patients.Frontiers in neurology · 2017Article
- Impaired carotid baroreflex control of arterial blood pressure in multiple sclerosis.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutonomic dysfunction is common in patients suffering from multiple sclerosis (MS) and orthostatic dizziness occurs in almost 50% of these patients. However, there have been no reports on postural orthostatic tachycardia syndrome (POTS) in patients suffering from MS.
methodsThe patients were included for analysis in this study if they had POTS with either a prior history of MS or having developed MS while being followed for POTS. Postural orthostatic tachycardia (POTS) is defined as symptoms of orthostatic intolerance(>6 months) accompanied by a heart rate increase of at least 30 beats/min (or a rate that exceeds 120 beats/min) that occurs in the first 10 minutes of upright posture or head up tilt test (HUTT) occurring in the absence of other chronic debilitating disorders. We identified nine patients with POTS who were suffering from MS as well. Each of these patients had been referred from various other centers for second opinions.
resultsThe mean age at the time of diagnosis of POTS was 49+/-9 years and eight of the 9 patients were women. Five patients (55%) had hyperlipidemia, 3 (33%) migraine and 2 (22%) patients had coronary artery disease and diabetes each. Fatigue and palpitations (on assuming upright posture) were the most common finding in our patients (9/9). All patients also had orthostatic dizziness. Syncope was seen in 5/9(55%) of patients. Four patients (44%), who did not have clear syncope, were having episodes of near syncope. The presence of POTS in our study population resulted in substantial limitation of daily activities. Following recognition and treatment of POTS, 6/9(66%), patients were able to resume daily activities of living. Their symptoms (especially fatigue and orthostatic intolerance) improved. The frequency and severity of syncope also improved. Three (33%) patients failed to show a good response to treatment.
conclusionPatients suffering from MS may manifest autonomic dysfunction by developing POTS. Early recognition and proper management may help improve the symptoms of POTS.
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