ReviewNature reviews. Nephrology2010
Metabolic acidosis: pathophysiology, diagnosis and management.
Review in Nature reviews. Nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 217 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill : A Multiple Center Randomized Clinical Trial (BICAR-ICU)
Built-in Calculator Optimizes Continuous Veno-venous Hemofiltration Prescription and Improves Therapeutic Quality in Critically-ill Acute Kidney Injury Patients
Who cites it
217 citing papers in PubMed, 2 syntheses or guidelines pooled it, 533 citations in OpenAlex.
- Peripheral venous blood gas analysis for the diagnosis of respiratory failure, hypercarbia and metabolic disturbance in adults.The Cochrane database of systematic reviews · 2025Pooled it
- Lactation Ketoacidosis: A Systematic Review of Case Reports.Medicina (Kaunas, Lithuania) · 2020Pooled it
- Additional Bicarbonate Infusion Complements WHO Rehydration Therapy in Children with Acute Diarrhea and Severe Dehydration Presenting with Severe Non-anion Gap Metabolic Acidemia: An Open Label Randomized Trial.Indian journal of pediatrics · 2025Trial
- Prolonged Water-Only Fasting Followed by a Whole-Plant-Food Diet Is a Potential Long-Term Management Strategy for Hypertension and Obesity.Nutrients · 2024Trial
- Neonatal encephalopathy therapy optimization for better neuroprotection with inhalation of COPediatric research · 2020Trial
- Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects - a randomized controlled trial.BMC nephrology · 2019Trial
- Randomized Clinical Trial of Ringer's Lactate Versus Chloride-Reduced Saline-Dextrose in Postoperative Kidney Transplantation.Kidney international reports · 2026Article
- Ventilator-Associated Pneumonia: The Role of Kidney-Lung Crosstalk and Renal Replacement Therapy, a Narrative Review.Journal of clinical medicine · 2026Review
- Association between postoperative arterial blood gas parameters and cognitive dysfunction following coronary artery bypass grafting: a prospective observational study.Irish journal of medical science · 2026Article
- SLC4A7/NBCn1 maintains intracellular pH to support mTORC1 activity and antibody-secreting cell differentiation.Nature communications · 2026Article
- Association between serum lactate trajectories and short-term mortality in pediatric acute kidney injury patients.Jornal de pediatria · 2026Article
- Acetazolamide and topiramate-induced clinically significant metabolic acidosis and weight loss in idiopathic intracranial hypertension: a case report and pharmacovigilance analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Article
- Review
- Article
- Is Preoperative Serum Bicarbonate an Undervalued Risk Factor in Cardiac Surgery?Journal of cardiovascular translational research · 2026Article
- Alterations of acid-base- and electrolyte status immediately following electroconvulsive therapy.Journal of neural transmission (Vienna, Austria : 1996) · 2026Observational
- Low Blood Glucose and Its Relation to Electrolyte Derangements and Metabolic Acidosis in Critically Ill Children in Malawi.The American journal of tropical medicine and hygiene · 2026Article
- Lactic acid drives NLRP3 inflammasome activation and caspase-1-like cytokine cleavage via intracellular acidification.Cell death & disease · 2026Article
- 101 machine learning algorithms for predicting mortality in critically ill patients with spinal cord injury and sarcopenia: a multi-database study.BMC medical informatics and decision making · 2026Observational
157 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic acidosis is characterized by a primary reduction in serum bicarbonate (HCO(3)(-)) concentration, a secondary decrease in the arterial partial pressure of carbon dioxide (PaCO(2)) of approximately 1 mmHg for every 1 mmol/l fall in serum HCO(3)(-) concentration, and a reduction in blood pH. Acute forms (lasting minutes to several days) and chronic forms (lasting weeks to years) of the disorder can occur, for which the underlying cause/s and resulting adverse effects may differ. Acute forms of metabolic acidosis most frequently result from the overproduction of organic acids such as ketoacids or lactic acid; by contrast, chronic metabolic acidosis often reflects bicarbonate wasting and/or impaired renal acidification. The calculation of the serum anion gap, calculated as [Na(+)] - ([HCO(3)(-)] + [Cl(-)]), aids diagnosis by classifying the disorders into categories of normal (hyperchloremic) anion gap or elevated anion gap. These categories can overlap, however. Adverse effects of acute metabolic acidosis primarily include decreased cardiac output, arterial dilatation with hypotension, altered oxygen delivery, decreased ATP production, predisposition to arrhythmias, and impairment of the immune response. The main adverse effects of chronic metabolic acidosis are increased muscle degradation and abnormal bone metabolism. Using base to treat acute metabolic acidosis is controversial because of a lack of definitive benefit and because of potential complications. By contrast, the administration of base for the treatment of chronic metabolic acidosis is associated with improved cellular function and few complications.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.