Evidence map›Paper›PMID 20308781›Full record

ArticleJournal of Alzheimer's disease : JAD2010

Statin users without an APOE-epsilon4 allele have increased insulin resistance.

Brian T VanFossen, G Stennis Watson, Laura D Baker, Kristoffer W Rhoads, Brenna A Cholerton, Mark A Reger, Stephen R Plymate, Gerald Schellenberg, Suzanne Craft

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brian T VanFossenGRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
G Stennis Watson
Laura D Baker
Kristoffer W Rhoads
Brenna A Cholerton
Mark A Reger
Stephen R Plymate
Gerald Schellenberg
Suzanne Craft

Funding

Glucose Regulation and Memory in Alzheimer's DiseaseR37AG010880 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CRAFT, SUZANNE · 2005 to 2014
$5.2M
NEUROBEHAVIOR, NEUROENDOCRINOLOGY, AND GENETICS OF ADT32AG000258 · NIA · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 1999 to 2013
$4.7M
Insulin, Norepinephrine, and Working Memory in AgingK01AG023640 · NIA · UNIVERSITY OF WASHINGTON · PI WATSON, G STENNIS · 2005 to 2009
$592k
NIA NIH HHS K01 AG023640NIA NIH HHS K01AG23640NIA NIH HHS R37 AG010880NIA NIH HHS R37AG010880NIA NIH HHS T32 AG000258
6 · The paper itself

Abstract

The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE epsilon4- (i.e., not having an epsilon4 allele) statin users had higher HOMA-IR values compared with epsilon4+/statin users (p=0.0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele.

Indexed as

HypercholesterolemiaAgedAlzheimer DiseaseAnticholesteremic AgentsApolipoprotein E4DementiaDiabetes MellitusFemaleGenotypeHomeostasisHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMetabolic SyndromePrevalenceAnticholesteremic AgentsApolipoprotein E4Hydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID20308781
PMCPMC2945621

What OpenQuestion holds

Texttitle and abstract
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.