Evidence map›Paper›PMID 20308778›Full record

ReviewJournal of Alzheimer's disease : JAD2010

Neuronutrition and Alzheimer's disease.

Balenahalli N Ramesh, T S Sathyanarayana Rao, Annamalai Prakasam, Kumar Sambamurti, K S Jagannatha Rao

Open access · greenAbstract readReview
In one paragraph

Review in Journal of Alzheimer's disease : JAD, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  9. Modulating Effect of Diet on Alzheimer's Disease.Diseases (Basel, Switzerland) · 2019
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Epigenetic nutraceutical diets in Alzheimer's disease.The journal of nutrition, health & aging · 2014
    Review
  17. Transient dynamics of Aβ contribute to toxicity in Alzheimer's disease.Cellular and molecular life sciences : CMLS · 2014
    Review
  18. Article
  19. Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Balenahalli N RameshBiochemistry and Nutrition, Central Food Technological Research Institute, CSIR Unit, Mysore, India.
T S Sathyanarayana Rao
Annamalai Prakasam
Kumar Sambamurti
K S Jagannatha Rao
Central Food Technological Research Institute · INMedical University of South Carolina · USJSS Medical College and Hospital · IN

Funding

Cholesterol and amyloidogenesisR01AG022103 · NIA · UNIVERSITY OF SOUTH ALABAMA · PI SAMBAMURTI, KUMAR · 2003 to 2007
$1.7M
Regulation and Cell Biology of Beta-SecretaseR01AG023055 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SAMBAMURTI, KUMAR · 2004 to 2008
$1.2M
NIA NIH HHS AG022103NIA NIH HHS AG023055NIA NIH HHS R01 AG022103NIA NIH HHS R01 AG023055
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurological disorder resulting from both genetic and environmental factors with the latter being particularly important for the sporadic form of the disease. As such, diets rich in saturated fatty acids and alcohol, and deficient in antioxidants and vitamins appear to promote the onset of the disease, while diets rich in unsaturated fatty acids, vitamins, antioxidants, and wine likely suppress its onset. In addition, evidence suggests that diets rich in polyphenols and some spices suppress the onset of AD by scavenging free radicals and preventing oxidative damage. Metal ions are known to catalyze the production of free radicals and induce mental retardation or dementia, and several studies have also identified metals such as Pb, Fe, Al, Cu, and Zn in AD pathogenesis. While specific metal chelators have been tested for therapy, they have not been very successful, probably due to their late administration, i.e., after brain damage has been triggered. Since several dietary polyphenols are known to chelate metals, their routine use may also be protective against the onset of AD. In this review, we summarize beneficial dietary techniques in the fight against AD.

Indexed as

Alzheimer DiseaseDietAgedAlcohol DrinkingAmyloid beta-PeptidesApolipoproteins EAvitaminosisBrainEnergy IntakeFemaleHomocysteineHumansHypercholesterolemiaMaleMiddle AgedNerve DegenerationAmyloid beta-PeptidesApolipoproteins EHomocysteineVitamin E

Identifiers

PMID20308778
PMCPMC2931824
OpenAlexW2126866334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.