ArticleProceedings of the National Academy of Sciences of the United States of America2010
Two competing orientation patterns explain experimentally observed anomalies in growing actin networks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Cellular and Nuclear Forces: An Overview.Methods in molecular biology (Clifton, N.J.) · 2025Review
- On the generation of force required for actin-based motility.Scientific reports · 2024Article
- Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery.Mechanobiology in medicine · 2024Review
- Adaptive nonequilibrium design of actin-based metamaterials: Fundamental and practical limits of control.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism.Molecular biology of the cell · 2023Article
- On multistability and constitutive relations of cell motion on fibronectin lanes.Biophysical journal · 2023Article
- A network of mixed actin polarity in the leading edge of spreading cells.Communications biology · 2022Article
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- A strong nonequilibrium bound for sorting of cross-linkers on growing biopolymers.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Predictive assembling model reveals the self-adaptive elastic properties of lamellipodial actin networks for cell migration.Communications biology · 2020Article
- The Actin Cytoskeleton as an Active Adaptive Material.Annual review of condensed matter physics · 2020Article
- Building a dendritic actin filament network branch by branch: models of filament orientation pattern and force generation in lamellipodia.Biophysical reviews · 2018Review
- Ultrastructure of the actin cytoskeleton.Current opinion in cell biology · 2018Review
- Capping protein-controlled actin polymerization shapes lipid membranes.Nature communications · 2018Article
- Tracing Actin Filament Bundles in Three-Dimensional Electron Tomography Density Maps of Hair Cell Stereocilia.Molecules (Basel, Switzerland) · 2018Article
- A Robust Actin Filaments Image Analysis Framework.PLoS computational biology · 2016Article
- The More the Tubular: Dynamic Bundling of Actin Filaments for Membrane Tube Formation.PLoS computational biology · 2016Article
- Amplification of actin polymerization forces.The Journal of cell biology · 2016Article
- Branching and capping determine the force-velocity relationships of branching actin networks.Physical biology · 2013Article
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2 authors.
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Abstract
The lamellipodium of migrating animal cells protrudes by directed polymerization of a branched actin network. The underlying mechanisms of filament growth, branching, and capping can be studied in in vitro assays. However, conflicting results have been reported for the force-velocity relation of such actin networks, namely both convex and concave shapes as well as history dependencies. Here we model branching as a reaction that is independent of the number of existing filaments, in contrast to capping, which is assumed to be proportional to the number of existing filaments. Using both stochastic network simulations and deterministic rate equations, we show that such a description naturally leads to the stability of two qualitatively different stationary states of the system, namely a +/- 35 degrees and a +70/0/-70 degrees orientation pattern. Changes in network growth velocity induce a transition between these two patterns. For sufficiently different protrusion efficiency of the two network architectures, this leads to hysteresis in the growth velocity of actin networks under force. Dependent on the history of the system, convex and concave regimes are obtained for the force-velocity relation. Thus a simple generic model can explain the experimentally observed anomalies, with far reaching consequences for cell migration.
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