ArticleEndocrinology2010
The nuclear receptor cofactor receptor-interacting protein 140 is a positive regulator of amphiregulin expression and cumulus cell-oocyte complex expansion in the mouse ovary.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- A role for the transcriptional coregulator RIP140 in the control of muscle endurance fitness.JCI insight · 2025Article
- The roles of MAPK signaling pathway in ovarian folliculogenesis.Journal of ovarian research · 2025Review
- RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure.The Journal of clinical investigation · 2023Article
- The role of amphiregulin in ovarian function and disease.Cellular and molecular life sciences : CMLS · 2023Review
- Compromised Cumulus-Oocyte Complex Matrix Organization and Expansion in Women with PCOS.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Ovulation: Parallels With Inflammatory Processes.Endocrine reviews · 2019Review
- Overexpression and potential roles of NRIP1 in psoriasis.Oncotarget · 2016Article
- Growth Arrest Specific-1 (GAS1) Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in Mice.Biology of reproduction · 2016Article
- The effect of lysophosphatidic acid during in vitro maturation of bovine cumulus-oocyte complexes: cumulus expansion, glucose metabolism and expression of genes involved in the ovulatory cascade, oocyte and blastocyst competence.Reproductive biology and endocrinology : RB&E · 2015Article
- Transcriptomic diversification of developing cumulus and mural granulosa cells in mouse ovarian follicles.Biology of reproduction · 2015Article
- Prostaglandin E2 (EP) receptors mediate PGE2-specific events in ovulation and luteinization within primate ovarian follicles.Endocrinology · 2014Article
- EP3 receptor isoforms are differentially expressed in subpopulations of primate granulosa cells and couple to unique G-proteins.Reproduction (Cambridge, England) · 2013Article
- The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals.Development (Cambridge, England) · 2013Article
- Consequences of RAS and MAPK activation in the ovary: the good, the bad and the ugly.Molecular and cellular endocrinology · 2012Review
- Article
- Role of nuclear receptor corepressor RIP140 in metabolic syndrome.Biochimica et biophysica acta · 2011Review
- Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140).Journal of biological rhythms · 2011Article
- CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15.Molecular endocrinology (Baltimore, Md.) · 2010Article
- New insights into ovarian function.Handbook of experimental pharmacology · 2010Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The nuclear receptor cofactor receptor-interacting protein 140 (RIP140) is essential for cumulus cell-oocyte complex (COC) expansion, follicular rupture, and oocyte release during ovulation. The expression of many genes necessary for COC expansion is impaired in the absence of RIP140, but the studies herein document that their expression can be restored and COC expansion rescued by treatment with the epidermal growth factor (EGF)-like factor amphiregulin (AREG) both in vitro and in vivo. We demonstrate by several approaches that RIP140 is required for the expression of the EGF-like factors in granulosa cells, but the dependence of genes involved in cumulus expansion, including Ptgs2 Has2, Tnfaip6, and Ptx3, is indirect because they are induced by AREG. Treatment of granulosa cells with forskolin to mimic the effects of LH increases AREG promoter activity in a RIP140-dependent manner that 1) requires an intact cAMP response element in the proximal promoter region of the Areg gene and 2) involves its actions as a coactivator for cAMP response element-binding protein/c-Jun transcription factors. Although human chorionic gonadotropin and AREG coadministration is sufficient to restore ovulation fully in RIP140 heterozygous mice in vivo, both follicular rupture and ovulation remain impaired in the RIP140 null mice. Thus, we conclude that although the level of RIP140 expression in the ovary is a crucial factor required for the transient expression of EGF-like factors necessary for cumulus expansion, it also plays a role in other signaling pathways that induce follicular rupture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.