ArticleInfection and immunity2010
Zebrafish as a model host for Candida albicans infection.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Article
- Immersion-Based Candida albicans Infection in Adult Zebrafish Induces Distinct Behavioral, Immune and Oxidative Responses in a Dose- and Time-Dependent Manner.Current microbiology · 2026Article
- Article
- Systematic Review of Mammalian Models for Experimental Sporotrichosis: Pathogenesis, Methodological Variables, and Ethical Considerations.Animals : an open access journal from MDPI · 2026Review
- Interactions betweenInfection and immunity · 2026Article
- Farnesol remodels the peritoneal cavity immune environment influencingInfection and immunity · 2023Article
- Protection against lethal sepsis following immunization withInfection and immunity · 2023Article
- Strain variation in gene expression impact of hyphal cyclin Hgc1 in Candida albicans.G3 (Bethesda, Md.) · 2023Article
- A Comparative Analysis on the Innate Immune Responses ofInternational journal of molecular sciences · 2023Article
- Article
- Battle royale: Immune response on biofilms - host-pathogen interactions.Current research in immunology · 2023Review
- Article
- Zebrafish as model for studies in dentistry.Journal of orthodontic science · 2022Review
- Integrative analyses of mRNA and microRNA expression profiles reveal the innate immune mechanism for the resistance toFrontiers in immunology · 2022Article
- Immunopathogenesis of EmergingJournal of fungi (Basel, Switzerland) · 2021Article
- Zebrafish Models for the Safety and Therapeutic Testing of Nanoparticles with a Focus on Macrophages.Nanomaterials (Basel, Switzerland) · 2021Review
- In Vitro or In Vivo Models, the Next Frontier for Unraveling Interactions betweenJournal of fungi (Basel, Switzerland) · 2020Review
- Inhibitory Effect of Morin AgainstFrontiers in microbiology · 2020Article
- Candida albicans triggers NADPH oxidase-independent neutrophil extracellular traps through dectin-2.PLoS pathogens · 2019Article
- Candida albicans Infection Model in Zebrafish (Danio rerio) for Screening Anticandidal Drugs.Mycopathologia · 2019Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, the zebrafish model organism was developed to obtain a minivertebrate host system for a Candida albicans infection study. We demonstrated that C. albicans can colonize and invade zebrafish at multiple anatomical sites and kill the fish in a dose-dependent manner. Inside zebrafish, we monitored the progression of the C. albicans yeast-to-hypha transition by tracking morphogenesis, and we monitored the corresponding gene expression of the pathogen and the early host immune response. We performed a zebrafish survival assay with different C. albicans strains (SC5314, ATCC 10231, an hgc1 mutant, and a cph1/efg1 double mutant) to determine each strain's virulence, and the results were similar to findings reported in previous mouse model studies. Finally, using zebrafish embryos, we monitored C. albicans infection and visualized the interaction between pathogen and host myelomonocytic cells in vivo. Taken together, the results of this work demonstrate that zebrafish can be a useful host model to study C. albicans pathogenesis, and they highlight the advantages of using the zebrafish model in future invasive fungal research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.