ArticleThe Journal of physiology2010
Ganglionic transmission in a vasomotor pathway studied in vivo.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Patch-clamp analysis of nicotinic synapses whose strength straddles the firing threshold of rat sympathetic neurons.Frontiers in neuroscience · 2022Article
- Heightened sympathetic neuron activity and altered cardiomyocyte properties in spontaneously hypertensive rats during the postnatal period.Frontiers in synaptic neuroscience · 2022Article
- Isolation and Electrophysiology of Murine Sympathetic Postganglionic Neurons in the Thoracic Paravertebral Ganglia.Bio-protocol · 2021Article
- The role of the paravertebral ganglia in human sympathetic neural discharge patterns.The Journal of physiology · 2018Article
- Fifty years of microneurography: learning the language of the peripheral sympathetic nervous system in humans.Journal of neurophysiology · 2018Review
- HCN hyperpolarization-activated cation channels strengthen virtual nicotinic EPSPs and thereby elevate synaptic amplification in rat sympathetic neurons.Journal of neurophysiology · 2016Article
- Neurocardiology: a neurobiologist's perspective.The Journal of physiology · 2016Article
- Respiratory modulated sympathetic activity: a putative mechanism for developing vascular resistance?The Journal of physiology · 2015Article
- Virtual leak channels modulate firing dynamics and synaptic integration in rat sympathetic neurons: implications for ganglionic transmission in vivo.The Journal of physiology · 2015Article
- Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration: a whole cell recording study in situ.The Journal of physiology · 2014Article
- The meaning of spikes from the neuron's point of view: predictive homeostasis generates the appearance of randomness.Frontiers in computational neuroscience · 2014Article
- Remodeling of intrinsic cardiac neurons: effects of β-adrenergic receptor blockade in guinea pig models of chronic heart disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Processing of central and reflex vagal drives by rat cardiac ganglion neurones: an intracellular analysis.The Journal of physiology · 2011Article
- On the number of preganglionic neurons driving human postganglionic sympathetic neurons: a comparison of modeling and empirical data.Frontiers in neuroscience · 2011Article
- Chemical coding for cardiovascular sympathetic preganglionic neurons in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Weak and straddling secondary nicotinic synapses can drive firing in rat sympathetic neurons and thereby contribute to ganglionic amplification.Frontiers in neurology · 2010Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular recordings were made in vivo from 40 spontaneously active cells in the third lumbar sympathetic ganglion of urethane-anaesthetized rats. In 38/40 cells ongoing action potentials showed strong cardiac rhythmicity (93.4 +/- 1.9% modulation) indicating high barosensitivity and probable muscle vasoconstrictor (MVC) function. Subthreshold excitatory postsynaptic potentials (EPSPs) showed the same pattern. The 38 barosensitive neurons fired action potentials at 2.9 +/- 0.3 Hz. All action potentials were triggered by EPSPs, most of which were unitary events. Calculations indicated that <5% of action potentials were triggered by summation of otherwise subthreshold EPSPs. 'Dominant' synaptic inputs with a high safety factor were identified, confirming previous work. These were active in 24/38 cells and accounted for 32% of all action potentials; other ('secondary') inputs drove the remainder. Inputs (21 dominant, 19 secondary) attributed to single preganglionic neurons fired at 1.38 +/- 0.16 Hz. An average of two to three preganglionic neurons were estimated to drive each ganglion cell's action potentials. When cells were held hyperpolarized to block spiking, a range of spontaneous EPSP amplitudes was revealed. Threshold equivalent was defined as the membrane potential value that was exceeded by spontaneous EPSPs at the same frequency as the cell's original firing rate. In 10/12 cells examined, a continuum of EPSP amplitudes overlapped threshold equivalent. Small changes in cell excitability could therefore raise or lower the percentage of preganglionic inputs triggering action potentials. The results indicate that vasoconstrictor ganglion cells in vivo mostly behave not as 1:1 relays, but as continuously variable gates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.