ArticleThe Journal of physiology2010
Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- The voltage-gated KPlatelets · 2022Article
- Mechanisms Underlying Dichotomous Procoagulant COAT Platelet Generation-A Conceptual Review Summarizing Current Knowledge.International journal of molecular sciences · 2022Review
- Why do platelets express KPlatelets · 2021Review
- Therapeutic Antibodies Targeting Potassium Ion Channels.Handbook of experimental pharmacology · 2021Article
- The versatile Kv channels in the nervous system: actions beyond action potentials.Cellular and molecular life sciences : CMLS · 2020Review
- Article
- The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.American journal of hematology · 2018Review
- Article
- Transcriptomic analysis of the ion channelome of human platelets and megakaryocytic cell lines.Thrombosis and haemostasis · 2016Article
- Blood cells: an historical account of the roles of purinergic signalling.Purinergic signalling · 2015Review
- Role of voltage-gated K(+) channels in regulating Ca(2+) entry in rat cortical astrocytes.The journal of physiological sciences : JPS · 2015Article
- Endogenous animal toxin-like human β-defensin 2 inhibits own K(+) channels through interaction with channel extracellular pore region.Cellular and molecular life sciences : CMLS · 2015Article
- Article
- Physiological significance of delayed rectifier K(+) channels (Kv1.3) expressed in T lymphocytes and their pathological significance in chronic kidney disease.The journal of physiological sciences : JPS · 2015Review
- Expression of Kv1.3 potassium channels regulates density of cortical interneurons.Developmental neurobiology · 2013Article
- Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression.Journal of leukocyte biology · 2013Article
- Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells.EMBO molecular medicine · 2012Article
- Optogenetic photochemical control of designer K+ channels in mammalian neurons.Journal of neurophysiology · 2011Article
- Compensatory thrombopoietin production from the liver and bone marrow stimulates thrombopoiesis of living rat megakaryocytes in chronic renal failure.Nephron extra · 2011Article
- Kv1.3: a potential pharmacological target for diabetes.Acta pharmacologica Sinica · 2010Review
Corrections and comments
- Commented on by
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
A delayed rectifier voltage-gated K(+) channel (Kv) represents the largest ionic conductance of platelets and megakaryocytes, but is undefined at the molecular level. Quantitative RT-PCR of all known Kv alpha and ancillary subunits showed that only Kv1.3 (KCNA3) is substantially expressed in human platelets. Furthermore, megakaryocytes from Kv1.3(/) mice or from wild-type mice exposed to the Kv1.3 blocker margatoxin completely lacked Kv currents and displayed substantially depolarised resting membrane potentials. In human platelets, margatoxin reduced the P2X(1)- and thromboxaneA(2) receptor-evoked [Ca(2+)](i) increases and delayed the onset of store-operated Ca(2+) influx. Megakaryocyte development was normal in Kv1.3(/) mice, but the platelet count was increased, consistent with a role of Kv1.3 in apoptosis or decreased platelet activation. We conclude that Kv1.3 forms the Kv channel of the platelet and megakaryocyte, which sets the resting membrane potential, regulates agonist-evoked Ca(2+) increases and influences circulating platelet numbers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.