ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2010
Mutations and quantitative genetic variation: lessons from Drosophila.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 100 citations in OpenAlex.
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- The condition-dependence of male genital size and shape.Ecology and evolution · 2024Article
- A possible genomic footprint of polygenic adaptation on population divergence in seed beetles?Ecology and evolution · 2022Article
- Inter- and intraspecific variation in mycotoxin tolerance: A study of fourEcology and evolution · 2022Article
- Natural variation in Drosophila shows weak pleiotropic effects.Genome biology · 2022Article
- Interplay between extreme drift and selection intensities favors the fixation of beneficial mutations in selfing maize populations.Genetics · 2021Article
- Microevolutionary Dynamics of Chicken Genomes under Divergent Selection for Adiposity.iScience · 2020Article
- Review
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- Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits.G3 (Bethesda, Md.) · 2019Article
- Multi-trait Improvement by Predicting Genetic Correlations in Breeding Crosses.G3 (Bethesda, Md.) · 2019Article
- Genome-Wide Association Analysis of Anoxia Tolerance inG3 (Bethesda, Md.) · 2019Article
- Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila.PLoS genetics · 2019Article
- Influence of a growth hormone transgene on the genetic architecture of growth-related traits: A comparative analysis between transgenic and wild-type coho salmon.Evolutionary applications · 2018Article
- Dissection of the molecular bases of genotype x environment interactions: a study of phenotypic plasticity of Saccharomyces cerevisiae in grape juices.BMC genomics · 2018Article
- Biocontrol characteristics of the fruit fly pupal parasitoid Trichopria drosophilae (Hymenoptera: Diapriidae) emerging from different hosts.Scientific reports · 2018Article
- Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits.Genes, brain, and behavior · 2018Article
- Dissecting genetic architecture of startle response in Drosophila melanogaster using multi-omics information.Scientific reports · 2017Article
- Natural and laboratory mutations in kuzbanian are associated with zinc stress phenotypes in Drosophila melanogaster.Scientific reports · 2017Article
Corrections and comments
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1 author at 1 institution in 1 country.
Funding
Abstract
A central issue in evolutionary quantitative genetics is to understand how genetic variation for quantitative traits is maintained in natural populations. Estimates of genetic variation and of genetic correlations and pleiotropy among multiple traits, inbreeding depression, mutation rates for fitness and quantitative traits and of the strength and nature of selection are all required to evaluate theoretical models of the maintenance of genetic variation. Studies in Drosophila melanogaster have shown that a substantial fraction of segregating variation for fitness-related traits in Drosophila is due to rare deleterious alleles maintained by mutation-selection balance, with a smaller but significant fraction attributable to intermediate frequency alleles maintained by alleles with antagonistic pleiotropic effects, and late-age-specific effects. However, the nature of segregating variation for traits under stabilizing selection is less clear and requires more detailed knowledge of the loci, mutation rates, allelic effects and frequencies of molecular polymorphisms affecting variation in suites of pleiotropically connected traits. Recent studies in D. melanogaster have revealed unexpectedly complex genetic architectures of many quantitative traits, with large numbers of pleiotropic genes and alleles with sex-, environment- and genetic background-specific effects. Future genome wide association analyses of many quantitative traits on a common panel of fully sequenced Drosophila strains will provide much needed empirical data on the molecular genetic basis of quantitative traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.