ArticleEnvironmental health perspectives2010
Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Gene-air pollution interaction and cardiovascular disease: a review.Progress in cardiovascular diseasesPooled it
- Vascular responses to long- and short-term exposure to fine particulate matter: MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution).Journal of the American College of Cardiology · 2012Trial
- Synergistic effects of genetic susceptibility and air pollution on cardiovascular disease.American journal of preventive cardiology · 2026Article
- Association of the ADRB2 rs1042714 variant with retinopathy of prematurity highlights the importance of the renin-angiotensin-aldosterone system.Scientific reports · 2025Article
- Structural and social determinants of health: The multi-ethnic study of atherosclerosis.PloS one · 2024Article
- Social Determinants of Health Factors for Gene-Environment COVID-19 Research: Challenges and Opportunities.Advanced genetics (Hoboken, N.J.) · 2022Article
- Exposure to Elevated Nitrogen Dioxide Concentrations and Cardiac Remodeling in Patients With Dilated Cardiomyopathy.Journal of cardiac failure · 2022Observational
- Long-Term Exposures to Air Pollution and the Risk of Atrial Fibrillation in the Women's Health Initiative Cohort.Environmental health perspectives · 2021Article
- Association Between Traffic Count and Cardiovascular Mortality: A Prospective Cohort Study in Taiwan.Journal of epidemiology · 2021Article
- Associations of air pollution with obesity and body fat percentage, and modification by polygenic risk score for BMI in the UK Biobank.Environmental research · 2020Article
- Oxidative stress and the cardiovascular effects of air pollution.Free radical biology & medicine · 2020Review
- Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation.The pharmacogenomics journal · 2019Review
- A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers.Human genetics · 2019Review
- Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Cardiovascular magnetic resonance in an adult human population: serial observations from the multi-ethnic study of atherosclerosis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Review
- Residential distance to major roadways and cardiac structure in African Americans: cross-sectional results from the Jackson Heart Study.Environmental health : a global access science source · 2017Article
- Advances in Understanding Air Pollution and CVD.Global heart · 2016Review
- Residential Proximity to Major Roadways Is Not Associated with Cardiac Function in African Americans: Results from the Jackson Heart Study.International journal of environmental research and public health · 2016Article
- Air pollution and adverse cardiac remodeling: clinical effects and basic mechanisms.Frontiers in physiology · 2015Review
- Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundElevated left ventricular mass (LVM) is a strong predictor of negative cardiovascular outcomes, including heart failure, stroke, and sudden cardiac death. A relationship between close (< 50 m compared with > 150 m) residential proximity to major roadways and higher LVM has previously been described, but the mechanistic pathways that are involved in this relationship are not known. Understanding genetic factors that influence susceptibility to these effects may provide insight into relevant mechanistic pathways.
objectiveWe set out to determine whether genetic polymorphisms in genes affecting vascular and autonomic function, blood pressure, or inflammation influence the relationship between traffic proximity and LVM.
methodsThis was a cross-sectional study of 1,376 genotyped participants in the Multi-Ethnic Study of Atherosclerosis, with cardiac magnetic resonance imaging performed between 2000 and 2002. The impact of tagged single-nucleotide polymorphisms (tagSNPs) and inferred haplotypes in 12 candidate genes (ACE, ADRB2, AGT, AGTR1, ALOX15, EDN1, GRK4, PTGS1, PTGS2, TLR4, VEGFA, and VEGFB) on the relationship between residential proximity to major roadways and LVM was analyzed using multiple linear regression, adjusting for multiple potential confounders.
resultsAfter accounting for multiple testing and comparing homozygotes, tagSNPs in the type 1 angiotensin II receptor (AGTR1, rs6801836) and arachidonate 15-lipoxygenase (ALOX15, rs2664593) genes were each significantly (q < 0.2) associated with a 9-10% difference in the association between residential proximity to major roadways and LVM. Participants with suboptimal blood pressure control demonstrated stronger interactions between AGTR1 and traffic proximity.
conclusionsCommon polymorphisms in genes responsible for vascular function, inflammation, and oxidative stress appear to modify associations between proximity to major roadways and LVM. Further understanding of how genes modify effects of air pollution on CVD may help guide research efforts into specific mechanistic pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.