Evidence map›Paper›PMID 20307383›Full record

ArticleJournal of diabetes science and technology2010

Analysis of hemoglobin A1c from dried blood spot samples with the Tina-quantR II immunoturbidimetric method.

Trevor G Jones, Kimbrough D Warber, Billy D Roberts

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Dried Blood Spots to Assess Cardiovascular-Kidney-Metabolic Health.Journal of the American Heart Association · 2025
    Pooled it
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  6. Effects of spot size on biomarker levels of field-collected dried blood spots: A new algorithm for exact dried blood spot size measurement.American journal of human biology : the official journal of the Human Biology Council · 2022
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  7. Article
  8. Remote capillary blood collection for HbADiabetic medicine : a journal of the British Diabetic Association · 2022
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  10. HbADiabetic medicine : a journal of the British Diabetic Association · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Trevor G JonesHeritage Labs International, LLC, Olathe, Kansas 66062 , USA.
Kimbrough D Warber
Billy D Roberts
Olathe Public Schools · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemoglobin A1c (HbA1c) has been endorsed as a tool for the diagnosis of diabetes. This test requires instrumentation that may not be available in underdeveloped areas. Dried blood spot (DBS) samples collected by finger stick procedures offer a mechanism to transport samples to laboratories that do measure HbA1c.

methodsWhole blood (ethylenediaminetetraacetic acid) was applied to Ahlstrom 226 filter paper. These DBS samples were compared to whole blood samples using the Roche Tina-quant II immunoturbidometric assay. Hemoglobin A1c stability on DBS was assessed at three temperatures-4, 25, and 40 degrees C-for up to 9 days. A 44-day study was also done for DBS at 20-25 degrees C.

resultsThe Tina-quant II DBS method showed excellent agreement with whole blood HbA1c results (r(2) = 0.99) with a slight positive mean bias of 0.08 +/- 0.04% HbA1c (95% confidence interval). The variation in HbA1c on DBS samples subjected to different temperatures and times did not exceed 5.6%.

conclusionsDried blood spot samples represent an alternative to whole blood for HbA1c by measurement when transporting whole blood is not feasible.

Indexed as

Blood Chemical AnalysisBlood Specimen CollectionChromatography, High Pressure LiquidDiabetes MellitusDrug StabilityFingersGlycated HemoglobinHumansNephelometry and TurbidimetrySensitivity and SpecificityTime FactorsGlycated Hemoglobin

Identifiers

PMID20307383
PMCPMC2864158
OpenAlexW2119223272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.