Evidence map›Paper›PMID 20307353›Full record

Trial reportThe British journal of nutrition2010

Markers of cardiovascular risk are not changed by increased whole-grain intake: the WHOLEheart study, a randomised, controlled dietary intervention.

Iain A Brownlee, Carmel Moore, Mark Chatfield, David P Richardson, Peter Ashby, Sharron A Kuznesof, Susan A Jebb, Chris J Seal

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02236533 (Healthy Effects of an Innovative Probiotic Pasta), which is not on this map. Cited by 80 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02236533 nacompletednot on this mapstarted 2014, after this paper: background citation

Healthy Effects of an Innovative Probiotic Pasta

TypeinterventionalSponsorUniversity of ParmaRan2014 to 2015Enrolled40ConditionsOBESITY, INFLAMMATION, DYSLIPIDEMIA, CONSTIPATIONArmswhole grain pasta
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Iain A BrownleeSchool of Agriculture, Human Nutrition Research Centre, Food & Rural Development, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Carmel Moore
Mark Chatfield
David P Richardson
Peter Ashby
Sharron A Kuznesof
Susan A Jebb
Chris J Seal

Funding

Medical Research Council MC_U105960384Medical Research Council MC_U105960389Medical Research Council U.1059.00.013(60389)
6 · The paper itself

Abstract

Recommendations for whole-grain (WG) intake are based on observational studies showing that higher WG consumption is associated with reduced CVD risk. No large-scale, randomised, controlled dietary intervention studies have investigated the effects on CVD risk markers of substituting WG in place of refined grains in the diets of non-WG consumers. A total of 316 participants (aged 18-65 years; BMI>25 kg/m2) consuming < 30 g WG/d were randomly assigned to three groups: control (no dietary change), intervention 1 (60 g WG/d for 16 weeks) and intervention 2 (60 g WG/d for 8 weeks followed by 120 g WG/d for 8 weeks). Markers of CVD risk, measured at 0 (baseline), 8 and 16 weeks, were: BMI, percentage body fat, waist circumference; fasting plasma lipid profile, glucose and insulin; and indicators of inflammatory, coagulation, and endothelial function. Differences between study groups were compared using a random intercepts model with time and WG intake as factors. Although reported WG intake was significantly increased among intervention groups, and demonstrated good participant compliance, there were no significant differences in any markers of CVD risk between groups. A period of 4 months may be insufficient to change the lifelong disease trajectory associated with CVD. The lack of impact of increasing WG consumption on CVD risk markers implies that public health messages may need to be clarified to consider the source of WG and/or other diet and lifestyle factors linked to the benefits of whole-grain consumption seen in observational studies.

Indexed as

DietEdible GrainFeeding BehaviorAdipose TissueAdolescentAdultAgedBiomarkersBlood CoagulationBlood GlucoseBody Mass IndexCardiovascular DiseasesEndothelium, VascularFemaleFood HandlingHumansBiomarkersBlood GlucoseInsulinLipids

Identifiers

PMID20307353
PMCPMC3501710

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.