ArticleJournal of proteome research2010
Activation of aortic endothelial cells by oxidized phospholipids: a phosphoproteomic analysis.
Article in Journal of proteome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
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- MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer.Journal of visualized experiments : JoVE · 2018Article
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- JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma.Cell discovery · 2016Article
- Non-muscle myosin II in disease: mechanisms and therapeutic opportunities.Disease models & mechanisms · 2015Review
- Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.Cancer cell · 2015Article
- Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.PloS one · 2015Article
- Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin.PloS one · 2014Article
- High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature.Arteriosclerosis, thrombosis, and vascular biology · 2012Review
- Structural identification and cardiovascular activities of oxidized phospholipids.Circulation research · 2012Review
- Role of phospholipid oxidation products in atherosclerosis.Circulation research · 2012Review
- Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death.Molecular systems biology · 2012Article
- Differential regulation of endothelial cell permeability by high and low doses of oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine.American journal of respiratory cell and molecular biology · 2012Article
- Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A role for VEGFR2 activation in endothelial responses caused by barrier disruptive OxPAPC concentrations.PloS one · 2012Article
- Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling.Science signaling · 2011Article
- Regulation of platelet function by class B scavenger receptors in hyperlipidemia.Arteriosclerosis, thrombosis, and vascular biology · 2010Review
- The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.Oncogene · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have shown that oxidized products of the phospholipid PAPC (Ox-PAPC) are strong activators of aortic endothelial cells and play an important role in atherosclerosis and other inflammatory diseases. We and others have demonstrated that Ox-PAPC activates specific signaling pathways and regulates a large number of genes. Using a phosphoproteomic approach based on phosphopeptide enrichment and mass spectrometry analysis, we identified candidate changes in Ox-PAPC-induced protein phosphorylation of 228 proteins. Functional annotation of these proteins showed an enrichment of the regulation of cytoskeleton, junctional components, and tyrosine kinases, all of which may contribute to the phenotypic and molecular changes observed in endothelial cells treated with Ox-PAPC. Many changes in protein phosphorylation induced by Ox-PAPC are reported here for the first time and provide new insights into the mechanism of activation by oxidized lipids, including phosphorylation-based signal transduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.