ArticleEuropean journal of immunology2010
Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection.
Article in European journal of immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Changes in natural killer cell subsets in pediatric liver transplant recipients.Pediatric transplantation · 2012Trial
- Mechanisms of Tolerance Induction in Liver Transplantation: Lessons Learned from Fetomaternal Tolerance, Autoimmunity and Tumor Immunity.International journal of molecular sciences · 2024Review
- Recognition ofInnate immunity · 2023Review
- The Immunomodulatory Properties of Mesenchymal Stem Cells Play a Critical Role in Inducing Immune Tolerance after Liver Transplantation.Stem cells international · 2021Review
- Allogeneic ADSCs Induce the Production of Alloreactive Memory-CD8 T Cells through HLA-ABC Antigens.Cells · 2020Article
- Recipient natural killer cells alter the course of rejection of allogeneic heart grafts in rats.PloS one · 2019Article
- Article
- NK cells after transplantation: friend or foe.Immunologic research · 2014Review
- Article
- Alloimmune activation promotes anti-cancer cytotoxicity after rat liver transplantation.PloS one · 2014Article
- Effector mechanisms of rejection.Cold Spring Harbor perspectives in medicine · 2013Review
- Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands.Immunology letters · 2012Article
- Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient?Regenerative medicine · 2011Article
- Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Toll-like receptor 4 contributes to small intestine allograft rejection.Transplantation · 2010Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
NKG2D is a receptor expressed by NK cells and subsets of T lymphocytes. On NK cells, NKG2D functions as a stimulatory receptor that induces effector functions. We cloned and expressed two rat NKG2D ligands, both members of the RAE1 family, RAE1L and RRLT, and demonstrate that these ligands can induce IFN-gamma secretion and cytotoxicity by rat NK cells. To examine changes in expression of NKG2D and the NKG2D ligands RAE1L and RRLT after transplantation, we used a Dark Agouti (DA)-->Lewis rat model of liver transplantation. NKG2D expression was significantly increased in allogeneic liver grafts by day 7 post-transplant. Ligands of NKG2D, absent in normal liver, were readily detected in both syngeneic and allogeneic liver grafts by day 1 post-transplant. By day 7 post-transplant, hepatocyte RAE1L and RRLT expression was significantly and specifically increased in liver allografts. In contrast to acute rejection that develops in the DA-->Lewis model, transplantation of Lewis livers into DA recipients (Lewis-->DA) results in spontaneous tolerance. Interestingly, expression of RAE1L and RRLT is low in Lewis-->DA liver allografts, but significantly increased in DA-->Lewis liver allografts undergoing rejection. In conclusion, our results suggest that expression of NKG2D ligands may be important in allograft rejection.
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