ReviewJournal of molecular medicine (Berlin, Germany)2010
Activation transcription factor-4 and the acute vascular response to injury.
Review in Journal of molecular medicine (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Endothelial Ffar4 protects against diabetic kidney disease by potentiating endogenous retinoic acid metabolism.Cellular & molecular biology letters · 2026Article
- ATF4 Contributes to Abdominal Aortic Aneurysm Formation via Modulating M1 Macrophage Polarization and Inflammation.Aging and disease · 2024Article
- Melatonin Attenuates HInternational journal of molecular sciences · 2022Article
- Activating transcription factor 4 aggravates angiotensin II-induced cell dysfunction in human vascular aortic smooth muscle cells via transcriptionally activating fibroblast growth factor 21.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022Article
- Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease.Neuroscience letters · 2016Article
- Article
- Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide.PloS one · 2014Article
- HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells.PloS one · 2013Article
- Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFs.Nucleic acids research · 2012Article
- Article
- Upregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is a complex fibroproliferative-inflammatory process triggered by vascular injury. Transcription factors play an important role in the control of genes that effect critical changes in the vessel wall. Recent evidence indicates an emerging role for activation transcription factor 4 (ATF4), a master regulator for evolutionarily conserved mammalian stress response pathways, in cardiovascular pathologic settings. For example, in endothelial cells, ATF4 is induced by atherogenic factors such as oxidised phospholipids and homocysteine, and in monocytes, ATF4 is activated by hypoxia. In this context, ATF4 is thought to regulate pro-inflammatory signalling cascades and subsequent apoptosis. ATF4 is induced in aortic smooth muscle cells by fibroblast growth factor 2 and in the intact vessel wall following balloon angioplasty. Our own work indicates that ATF4 knockdown blocks injury-inducible intimal proliferation. Furthermore, studies in ATF4-deficient mice have established a role for ATF4 in diet-induced diabetes and hyperlipidaemia. In this article, we will review recent developments on the regulation of this intriguing nuclear protein and its transcriptional roles in the context of vascular injury and related disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.