ArticlePloS one2010
New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Genome-Wide Meta-Analysis of Sciatica in Finnish Population.PloS one · 2016Pooled it
- Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk.BMC musculoskeletal disorders · 2014Pooled it
- Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.Nature genetics · 2014Pooled it
- Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.Arthritis & rheumatology (Hoboken, N.J.) · 2014Pooled it
- Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis.International journal of molecular sciences · 2025Review
- Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort.PloS one · 2025Article
- Age-dependent genetic regulation of osteoarthritis: independent effects of immune system genes.Arthritis research & therapy · 2023Article
- Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score.Arthritis research & therapy · 2023Article
- Integrin Subunit Alpha M, ITGAM Nonsynonymous SNP Is Associated with Knee Osteoarthritis among Thais: A Case-Control Study.Current issues in molecular biology · 2023Article
- Multi-omics molecular biomarkers and database of osteoarthritis.Database : the journal of biological databases and curation · 2022Article
- Genetics of osteoarthritis.Osteoarthritis and cartilage · 2022Review
- Article
- The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.Calcified tissue international · 2021Review
- Osteoarthritis: an ancient disease, an unsolved conundrum.International orthopaedics · 2021Article
- Duration of symptoms prior to partial meniscectomy is not associated with the expression of osteoarthritis genes in the injured meniscus.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Article
- Integration of transcriptome-wide association study and messenger RNA expression profile to identify genes associated with osteoarthritis.Bone & joint research · 2020Article
- Association of GWAS-supported noncoding area loci rs404860, rs3117098, and rs7775228 with asthma in Chinese Zhuang population.Journal of clinical laboratory analysis · 2020Article
- Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples.Journal of neuroinflammation · 2019Article
- Genome-wide association study of knee pain identifies associations withCommunications biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of approximately 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43x10(-8) for rs7775228 and 6.73x10(-8) for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.